Toxoplasma gondi Antibody Profile in Patients with Leukemia or Lymphoma

Abstract

Abstract:

Blood samples were collected from patients with leukemia（n=150） or lymphoma（n=150） in the Cancer Hospital from March to September 2014. The specific antibodies（IgG， IgM）to， and circulating antigens（CAg） of Toxoplasma gondii were determined by ELISA. A 529 bp specific sequence was amplified by PCR from the genomic DNA of T. gondii. T. gondii-specific IgG positive rate in patients with leukemia and lymphoma were 16.0%（24/150） and 20.0%（30/150）， respectively， which were significantly higher than that of healthy persons（6.4%， 7/110）（P＜0.05）. IgM positive rate of the leukemia patients， lymphoma patients， and healthy persons was 2.7%（4/150）， 1.3%（2/150）， and 0.9%（1/110）（P＞0.05）， respectively. No significant difference was found in IgM and CAg positive rate among leukemia patients， lymphoma patients， and healthy persons （P＞0.05）. No specific band （529 bp） was detected in all samples.

Key words: Leukemia, Lymphoma, Toxoplasma gondii, Antibody

TIAN Meng-yuan1，HUANG Yun-hong2，HU Yun-fei2，PENG Feng-tao1，ZOU Cai-yan1，LI Yong-nian1 *. Toxoplasma gondi Antibody Profile in Patients with Leukemia or Lymphoma[J]. .

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Toxoplasma gondi Antibody Profile in Patients with Leukemia or Lymphoma

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