Abstract: Circumsporzoite protein (CSP) is found in all the mature malaria parasites, which forms a dense coat on the sporozoite′s surface. CSPs contain approximately 400 amino acids and are organized into three domains: an N-terminal domain containing a conserved pentapeptide called region Ⅰ, a highly repetitive species-specific central domain, and a C-terminal domain containing another conserved sequence called region Ⅱ. It has been reported that the CSP fulfills vital roles in invading to the mosquito′s salivary glands, binding sporozoite to liver cells, and inactivating host cell protein synthesis machinery. Recently, researches pointed out that both of the vaccine and the targeted-drug-delivery-system based on CSP antigen reveal an immense prospect. This review presents a compilation of the protein at the molecular characterization, function and application level that have been described to date.

Key words: Plasmodium, Circumsporozoite protein, Malaria vaccine, Targeted drug delivery system