Progress on Hydrolases-targeting Antiparasitic Prodrugs

›› 2012, Vol. 30 ›› Issue (2): 11-139-145.

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Progress on Hydrolases-targeting Antiparasitic Prodrugs

WEN Ai-Dan, ZHANG Hao-Bing*

National Institute of Parasitic Diseases，Chinese Center for Disease Control and Prevention；Key Laboratory of Parasite and Vector Biology，MOH；WHO Collaborating Centre for Malaria，Schistosomiasis and Filariasis，Shanghai 200025，China

Online:2012-04-30 Published:2012-09-28

Abstract

Abstract: 【Abstract】 Prodrug strategies have been used for drug optimization to overcome the drawbacks in pharmaceutics, pharmacokinetics and pharmacodynamics. Most enzymes involved in prodrug biotransformation are hydrolases，in which esterase and amidase have been widely researched. This review summarizes the recent progress in antiparasitic prodrugs based on both targets.

Key words: Prodrug, Hydrolase, Esterase, Amidase, Antiparasitic drug

WEN Ai-Dan, ZHANG Hao-Bing*. Progress on Hydrolases-targeting Antiparasitic Prodrugs[J]. , 2012, 30(2): 11-139-145.

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Progress on Hydrolases-targeting Antiparasitic Prodrugs

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