National syndromic surveillance of angiostrongyliasis in China from 2009 to 2025

doi:10.12140/j.issn.1000-7423.2026.04.003

Abstract

Abstract:

Objective To investigate the current prevalence of angiostrongyliasis in China, so as to provide insight into angiostrongyliasis control programmes. Methods Data pertaining to human angiostrongyliasis cases and surveillance of intermediate host snails were collected from 12 pilot areas conducting syndromic surveillance for angiostrongyliasis in China from 2009 to 2025. The geographical distribution of angiostrongyliasis cases, prevalence of Angiostrongylus cantonensis infection in snail hosts, and distribution and spread of snail hosts were analyzed. Results A total of 251 angiostrongyliasis cases were reported from the pilot areas from 2009 to 2025, including 88 clinically diagnosed cases and 163 suspected cases. Most cases were reported from Dali Prefecture (63 clinically diagnosed cases and 10 suspected cases) and Kunming City of Yunnan Province (12 clinically diagnosed cases and 8 suspected cases), and Fuzhou City of Fujian Province (11 clinically diagnosed cases and 99 suspected cases), and a few cases were reported from Jinghong City of Yunnan Province (26 suspected cases), and Xiamen City of Fujian Province (one clinically diagnosed case and 15 suspected cases). The number of reported angiostrongyliasis cases showed an overall tendency towards a decline from 2009 to 2025. Surveillance on intermediate host snails identified Pomacea spp. and Lissachatina spp. as predominant intermediate snail hosts, and the overall prevalence rates of A. cantonensis infections were 1.07% (2 647/247 801) in Pomacea spp. and 9.62% (878/9 124) in Lissachatina spp., respectively. A. cantonensis infection was detected in Pomacea spp. each year from 2009 to 2025, with the highest prevalence recorded in 2009 (3.13%, 109/3 480), while A. cantonensis infection was found in Lissachatina spp. in 9 years from 2009 to 2025, with the highest prevalence recorded in 2016 (31.61%, 165/522). The distributions of both Pomacea spp. and Lissachatina spp. showed a tendency towards expansion northwards. Pomacea spp. has already invaded in the southern part of the Qinling-Huaihe Line and colonized in two provinces of Shandong and Henan. Conclusion The overall prevalence of angiostrongyliasis appeared a tendency towards a decline in the pilot areas of China from 2009 to 2025. However, geographical distributions of invasive Pomacea spp. and Lissachatina spp. continue to expand, which increase the risk of angiostrongyliasis transmission.

Key words: Angiostrongyliasis, Syndromic surveillance, Pomacea, Lissachatina

CLC Number:

R532.19

HAN Qingchi, YANG Limin, ZHU Zelin, ZHANG Yi, CHEN Junhu, GUO Yunhai, LV Shan. National syndromic surveillance of angiostrongyliasis in China from 2009 to 2025[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2026, 44(4): 477-483.

Figures/Tables 4

Table 1

Surveillance on angiostrongyliasis case in pilot areas of syndromic surveillance for angiostrongyliasis in China from 2009 to 2025

年份 Year		云南大理 Dali, Yunnan				云南昆明 Kunming, Yunnan				云南景洪 Jinhong, Yunnan					福建福州 Fuzhou, Fujian				福建厦门 Xiamen, Fujian				广东清远 Qinyuan, Guangdong
年份 Year		临床诊断病例 Clinically diagnosed case		疑似病例Suspected case		临床诊断病例 Clinically diagnosed case		疑似病例Suspected case		临床诊断病例 Clinically diagnosed case			疑似病例 Suspected case		临床诊断病例 Clinically diagnosed case		疑似病例 Suspected case		临床诊断病例 Clinically diagnosed case		疑似病例 Suspected case		临床诊断病例 Clinically diagnosed case		疑似病例 Suspected case
2009		0		0		0		0		0			0		3		0		0		0		-		-
2010		2		0		3		1		0			26		3		99		0		15		0		0
2011		19		6		9		1		0			0		2		0		1		0		0		0
2012		2		1		0		0		0			0		0		0		0		0		0		5
2013		6		0		0		6		0			0		0		0		0		0		0		0
2014		6		1		0		0		0			0		0		0		0		0		0		0
2015		4		1		0		0		0			0		0		0		0		0		0		0
2016		11		1		0		0		0			0		0		0		0		0		0		0
2017		0		0		0		0		0			0		0		0		0		0		0		0
2018		1		0		0		0		0			0		0		0		0		0		0		0
2019		1		0		0		0		0			0		0		0		0		0		0		0
2020		4		0		0		0		0			0		0		0		0		0		0		0
2021		3		0		0		0		0			0		0		0		0		0		0		0
2022		0		0		0		0		0			0		0		0		0		0		0		0
2023		1		0		0		0		0			0		3		0		0		0		0		0
2024		1		0		0		0		0			0		0		0		0		0		0		0
2025		2		0		0		0		0			0		0		0		0		0		0		0
合计 Total		63		10		12		8		0			26		11		99		1		15		0		5
年份 year	广东开平 Kaiping, Guangdong				上海黄浦 Huangpu, Shanghai				上海松江 Songjiang, Shanghai			四川自贡 Zigong, Sichuan				山东兖州 Yanzhou, Shandong				海南儋州 Danzhou, Hainan				合计 Total
年份 year	临床诊断病例 Clinically diagnosed case		疑似病例 Suspected case		临床诊断病例 Clinically diagnosed case		疑似病例 Suspected case		临床诊断病例 Clinically diagnosed case		疑似病例 Suspected case	临床诊断病例 Clinically diagnosed case		疑似病例 Suspected case		临床诊断病例 Clinically diagnosed case		疑似病例 Suspected case		临床诊断病例 Clinically diagnosed case		疑似病例 Suspected case		临床诊断病例 Clinically diagnosed case	疑似病例 Suspected case
2009	-		-		-		-		-		-	-		-		-		-		-		-		3	0
2010	0		0		-		-		-		-	-		-		-		-		-		-		8	141
2011	0		0		-		-		-		-	-		-		-		-		-		-		31	7
2012	0		0		-		-		-		-	-		-		-		-		-		-		2	6
2013	0		0		0		0		0		0	-		-		-		-		-		-		6	6
2014	0		0		0		0		0		0	-		-		-		-		-		-		6	1
2015	0		0		0		0		0		0	-		-		-		-		-		-		4	1
2016	0		0		0		0		0		0	-		-		-		-		-		-		11	1
2017	0		0		0		0		0		0	-		-		-		-		-		-		0	0
2018	0		0		0		0		0		0	-		-		-		-		-		-		1	0
2019	0		0		0		0		0		0	-		-		-		-		-		-		1	0
2020	0		0		0		0		0		0	-		-		-		-		-		-		4	0
2021	0		0		0		0		0		0	-		-		-		-		-		-		3	0
2022	0		0		0		0		0		0	0		0		-		-		-		-		0	0
2023	0		0		0		0		0		0	0		0		1		0		0		0		5	0
2024	0		0		0		0		0		0	0		0		0		0		0		0		1	0
2025	0		0		0		0		0		0	0		0		0		0		0		0		2	0
合计 Total	0		0		0		0		0		0	0		0		1		0		0		0		88	163

Table 1

Table 2

Fig. 1

Fig. 2

References 19

[1]	Wang QP, Chen XG, Lun ZR. Invasive freshwater snail, China[J]. Emerg Infect Dis, 2007, 13(7): 1119-1120.
[2]	Lv S, Zhang Y, Liu HX, et al. Invasive snails and an emerging infectious disease: results from the first national survey on Angiostrongylus cantonensis in China[J]. PLoS Negl Trop Dis, 2009, 3(2): e368.
[3]	吕山, 周晓农, 张仪, 等. 中国大陆广州管圆线虫病流行病学分析[J]. 中国人兽共患病学报, 2006, 22(10): 987-988.
	Lv S, Zhou XN, Zhang Y, et al. Epidemiological analysis of angiostrongyliasis cantonensis in Chinese mainland[J]. Chin J Zoonoses, 2006, 22(10): 987-988.
[4]	Lv S, Guo YH, Wei FR, et al. Control of eosinopilic meningitis caused by Angiostrongylus cantonensis in China[J]. Adv Parasitol, 2020, 110: 269-288.
[5]	陈凤, 陈绍荣, 李科荣, 等. 大理市1起食用螺肉引起的广州管圆线虫病暴发调查[J]. 中国血吸虫病防治杂志, 2011, 23(6): 687-690.
	Chen F, Chen SR, Li KR, et al. Investigation on outbreak of angiostrongyliasis cantonensis due to consumption of snail food in Dali City[J]. Chin J Schisto Control, 2011, 23(6): 687-690. (in Chinese)
[6]	罗静雯, 田洪春, 李春燕, 等. 四川省首次发现本地感染广州管圆线虫病病例的调查[J]. 预防医学情报杂志, 2022, 38(5): 635-637.
	Luo JW, Tian HC, Li CY, et al. Investigation on the first found local cases of angiostrongyliasis cantonensis in Sichuan Province[J]. J Prev Med Inf, 2022, 38(5): 635-637. (in Chinese)
[7]	李曰进, 闫燕, 申艳梅, 等. 山东省输入性广州管圆线虫病1例[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(4): 554-556.
	Li YJ, Yan Y, Shen YM, et al. A case of imported angiostrongyliasis in Shandong[J]. Chin J Parasitol Parasit Dis, 2024, 42(4): 554-556. (in Chinese)
[8]	刘世英, 李旭芳, 潘火云, 等. 18例儿童中重型广州管圆线虫病临床特点与治疗分析[J]. 热带病与寄生虫学, 2025, 23(2): 110-115.
	Liu SY, Li XF, Pan HY, et al. Clinical pictures and treatment of moderate to severe pediatric angiostrongyliasis in 18 cases[J]. J Trop Dis Parasitol, 2025, 23(2): 110-115. (in Chinese)
[9]	黄梦宇, 陈帝坤, 陈慧儒, 等. 海口市湿地公园褐云玛瑙螺广州管圆线虫感染情况调查[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(5): 640-643.
	Huang MY, Chen DK, Chen HR, et al. Investigation on Angiostrongylus cantonensis infection in Achatina fulica in Haikou wetland park[J]. Chin J Parasitol Parasit Dis, 2023, 41(5): 640-643. (in Chinese)
[10]	刘玉婷, 厉广栩. 儿童重型广州管圆线虫病1例[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(6): 813-816.
	Liu YT, Li GX. Severe angiostrongyliasis in a child[J]. Chin J Parasitol Parasit Dis, 2022, 40(6): 813-816. (in Chinese)
[11]	罗智强, 廖建湘. 儿童广州管圆线虫脑膜炎3例临床特点及脑脊液宏基因二代测序诊断价值分析[J]. 中国实用儿科杂志, 2022, 37(1): 59-62.
	Luo ZQ, Liao JX. Analysis of clinical features of Angiostrongylus cantonensis meningitis in 3 children and the value of metagenomics next-generation sequencing of cerebrospinal fluid in its diagnosis[J]. Chin J Pract Pediatr, 2022, 37(1): 59-62.
[12]	中国医师协会儿科医师分会感染和传染病学组, 《中华实用儿科临床杂志》编辑委员会, 广州市儿科质量控制中心. 儿童广州管圆线虫病的诊断、治疗和预防专家共识[J]. 中华实用儿科临床杂志, 2026, 41(1): 2-8.
	The Pediatric Group of Chinese Medical Doctor Association Committee on Infection and Infectious Diseases, Editorial Board of Chinese Journal of Applied Clinical Pediatrics, Guangzhou Pediatric Quality Control Center. Expert consensus on the diagnosis, treatment, and prevention of angiostrongyliasis cantonensis in children[J]. Chin J Appl Clin Pediatr, 2026, 41(1): 2-8.
[13]	Andrus PS, Han QC, Yang LM, et al. Population genetic diversity of invasive Pomacea snails and surveillance of Angiostrongylus cantonensis in Shanghai, East China[J]. Parasit Vectors, 2026, 19(1): 162.
[14]	蒋玲, 李天美, 刘榆华, 等. 大理白族自治州入侵福寿螺分子鉴定与种群遗传学研究[J]. 中国血吸虫病防治杂志, 2025, 37(6): 626-636.
	Jiang L, Li TM, Liu YH, et al. Molecular identification and population genetics of the invasive Pomacea spp. in Dali Bai Autonomous Prefecture[J]. Chin J Schisto Control, 2025, 37(6): 626-636. (in Chinese)
[15]	Yang QQ, Liu SW, He C, et al. Distribution and the origin of invasive apple snails, Pomacea canaliculata and P. maculata (Gastropoda ∶ Ampullariidae) in China[J]. Sci Rep, 2018, 8(1): 1185.
[16]	高素真, 舒畅, 吕鑫, 等. 海南省玛瑙螺物种鉴定及其感染广州管圆线虫的调查[J]. 热带医学杂志, 2024, 24(4): 480-485, 489.
	Gao SZ, Shu C, Lv X, et al. Species identification of Achatina and investigation of its infection with Angiostrongylus cantonensis in Hainan Province[J]. J Trop Med, 2024, 24(4): 480-485, 489. (in Chinese)
[17]	邓秀, 夏茄翔, 刘虎涛, 等. 2021-2025年四川省福寿螺广州管圆线虫感染调查[J]. 热带医学杂志, 2026, 26(3): 416-419.
	Deng X, Xia QX, Liu HT, et al. Survey of Angiostrongylus cantonensis infection in Pomacea canaliculata in Sichuan Province from 2021 to 2025[J]. J Trop Med, 2026, 26(3): 416-419.
[18]	范泽涵, 詹惕, 孙成松, 等. 马鞍山市首次发现福寿螺感染广州管圆线虫[J]. 热带病与寄生虫学, 2024, 22(6): 364-366, 374.
	Fan ZH, Zhan T, Sun CS, et al. First detection of Angiostronylus cantonensis infection in Pomacea canaliculata in Ma’anshan City[J]. J Trop Dis Parasitol, 2024, 22(6): 364-366, 374. (in Chinese)
[19]	相慢玉, 何馥男, 张仪, 等. 入侵我国的褐云玛瑙螺线粒体全基因系统发育分析[J]. 热带医学杂志, 2020, 20(4): 469-473.
	Xiang MY, He FN, Zhang Y, et al. Phylogenetic analysis of the mitochondrial genomes invading giant African snail Achatina fulica in China[J]. J Trop Med, 2020, 20(4): 469-473.

年份	福寿螺 Pomacea			玛瑙螺 Lissachatina			环棱螺 Bellamya			圆田螺 Cipangopaludina
年份	检测只数 No. tested	阳性只数 No. positive	感染率/% Infection rate/%	检测只数 No. tested	阳性只数 No. positive	感染率/% Infection rate/%	检测只数 No. tested	阳性只数 No. positive	感染率/% Infection rate/%	检测只数 No. tested	阳性只数 No. positive	感染率/% Infection rate/%
2009	3 480	109	3.13	0	0	0	1 950	3	0.15	506	0	0
2010	6 037	177	2.93	300	0	0	5 389	3	0.06	4 300	0	0
2011	27 911	570	2.04	500	0	0	9 123	13	0.14	11 590	0	0
2012	20 994	645	3.07	1 521	187	12.29	15 285	8	0.05	16 103	0	0
2013	19 345	273	1.41	1 901	0	0	22 548	4	0.02	16 344	0	0
2014	11 237	152	1.35	761	18	2.37	14 307	2	0.01	3 751	0	0
2015	12 946	68	0.53	1 879	334	17.78	9 298	1	0.01	8 009	0	0
2016	23 172	95	0.41	522	165	31.61	408	2	0.49	0	0	0
2017	13 842	47	0.34	389	58	14.91	1 132	0	0	186	0	0
2018	6 292	88	1.40	0	0	0	8 922	0	0	5 280	0	0
2019	28 353	95	0.34	114	0	0	13 743	0	0	8 163	1	0.01
2020	20 086	112	0.56	0	0	0	4 912	1	0.02	2 520	0	0
2021	15 151	58	0.38	0	0	0	4 130	0	0	0	0	0
2022	14 527	82	0.56	110	4	3.64	-	-	-	-	-	-
2023	4 236	51	1.20	483	86	17.81	-	-	-	-	-	-
2024	15 737	10	0.06	400	22	5.50	-	-	-	-	-	-
2025	4 455	15	0.34	244	4	1.64	-	-	-	-	-	-