Progress in genotyping of Pneumocystis jirovecii

doi:10.12140/j.issn.1000-7423.2021.06.018

Abstract

Abstract:

Pneumocystis jirovecii, an opportunistic pathogenic fungus, may cause severe pneumocystis pneumonia (PCP), especially in immunodeficient patients. Pneumocystis was initially classified as a protozoan, named P. carinii. However, it was phylogenetically reclassified as an atypical fungal pathogen at late 1980s, which was confirmed with genetic sequence analyses, using molecular biology techniques. Due to lack of in vitro culture method, it has been difficult to clearly understand the patho-biological and epidemiological characteristics of Pneumocystis. With the wide application of molecular biology techniques, genotyping method for Pneumocystis has been extensively developed in recent years, however, no international standardization and global consensus on the genotyping scheme has been reached, hindering the investigation of epidemiology, population structure, source of infection, transmission characteristics of the clinical isolate of P. jirovecii, and in turn impeding the studies on the pathogenesis and control strategy of PCP. This review summarizes the progress in research on the genotyping approaches for P. jirovecii, in commemorating the 20th anniversary of its renaming.

Key words: Pneumocystis jirovecii, Genotyping, Multilocus sequence typing

CLC Number:

R372

XUE Ting, DU Wei-qin. Progress in genotyping of Pneumocystis jirovecii[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(6): 842-847.

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