Abstract: 　Objective To develop a combination of molluscicide/insecticide with a good molluscicidal effect, especially an inhibitory effect on climbing upward of Oncomelania hupensis . Methods Experiments on molluscicidal and snail climbing inhibition effect of the combination of niclosamide and shachongding [(dimethylamine) trithacyclohexane hydrochloride] were conducted by immersion and spraying in laboratory. Results The combination of niclosamide (0.2 mg/L) and shachongding (0.1 mg/L) showed an inhibition of 92.67% of snails to climb up. There was no significant difference in molluscicidal effect between the combination (LC 90 0.198 mg/L) and niclosamide alone (LC 90 0.207 mg/L). Conclusion The combination showed an effective inhibition on the climbing upward of snails in water so as to improve the molluscicidal effect and reduce the cost of mollusciciding.

Key words: niclosamide, shachongding [(dimethylamine) trithacyclohexane hydrochloride], molluscicide, combination, Oncomelania hupensis