Informatics Analysis of Malate Dehydrogenase from Taenia saginata asiatica

›› 2008, Vol. 26 ›› Issue (3): 17-227.

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Informatics Analysis of Malate Dehydrogenase from Taenia saginata asiatica

HUANG Jiang^{1 *}， HU Xu-chu²， HUANG Yan²， YU Xin-bing²，BAO Huai-en¹， LANG Shu-yuan¹， LIAO Xing-jiang¹

1 Department of Parasitology, Guiyang Medical University, Guiyang 550004, China; 2 Department of Parasitology, Sun Yat-sen Medical College, Sun Yat-sen University, Guangzhou 510080, China

Received:1900-01-01 Revised:1900-01-01 Online:2008-06-30 Published:2008-06-30

Abstract

Abstract: Tools from bioinformatics websites such as NCBI， ExPaSy were used for the analysis. The malate dehy-drogenase full-length gene from Taenia saginata asiatica was 1 212 bp in length， with a coding region of 30-1 028 bp and coding 332 amino acids. It was a complete and full-length gene compared with the homologues in GenBank. The protein showed no transmembrane region， with stable phycical-chemical characteristics. Three major linear epitopes located aa95-aa100, aa322-aa327 and aa117-aa122, with certain distance from each other on the surface of spatial structure of malate dehydrogenase（MDH）. The last one was the linear epitope of Taenia. This cytosolic malate dehydrogenase gene is a potential antigen for diagnosis.

Key words: Taenia saginata asiatica, Malate dehydrogenase（MDH）, cDNA, Bioinformatics

HUANGJiang*;HUXu-chu;HUANGYan;YUXin-bing;BAOHuai-en;LANGShu-yuan;LIAOXing-jiang. Informatics Analysis of Malate Dehydrogenase from Taenia saginata asiatica[J]. , 2008, 26(3): 17-227.

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Informatics Analysis of Malate Dehydrogenase from Taenia saginata asiatica

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