Risk factors for malaria: a Meta-analysis

Abstract

Abstract:

To analyze the risk factors for malaria, case-control studies on malaria risk factors from 1990 to 2016 were collected from databases of PubMed, CNKI, EMbase and Cochrane.The odds ratio (OR) and 95% confidence interval (95%CI) were calculated for each factor.Meta-analysis was performed with the RevMan 5.2 software.Eighteen case-control studies involving 3 509 cases and 12 447 controls were finally included for the analysis.Meta-analysis results revealed risk factors of never or rarely using a mosquito net, housing structure for the temporary use, exposure to the endemic areas 1 month before malaria onset, malaria occurrence in family members or neighborhood in the past year, with pooled OR values (95%CI) of 1.62 (1.42,1.85), 1.57 (1.09,2.28), 2.88 (2.00,4.16), and 3.59 (2.93,4.40), respectively (all P < 0.05).The results suggest the importance of paying attention to populations who have contacts with patients and those with an epidemiological history, and strengthenting the health education of personal protection and so on.

Key words: Malaria, Risk factor, Meta analysis

CLC Number:

R531.3

Xu-can ZENG, Chun-hai LUO, Zu-rui LIN, Zi-you ZHOU, Quan LV, Xing-wu ZHOU, Jian-xiong LI, Yao-wu ZHOU, Xiao-dong SUN. Risk factors for malaria: a Meta-analysis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2017, 35(6): 594-597.

Figures/Tables 3

References 30

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发病因素	纳入研究文献	效应模型	合并OR 值（95%CI）
很少或从不使用蚊帐	[2, 3, 12, 13, 15, 16, 19, 20, 23, 24]	固定	1.62（1.42,1.85）^a
性别（男性）	[2, 4-6, 13, 16, 17, 24]	固定	1.07（0.93,1.22）^b
未采取其他防蚊措施	[4-6, 12-14, 16, 18, 19, 21, 24]	随机	1.50（0.99,2.25）^b
临时性的房屋结构	[4, 13, 15, 18, 21, 23]	随机	1.57（1.09,2.28）^a
发病前1个月内到过疟疾流行区	[4, 5, 13, 15, 22]	固定	2.88（2.00,4.16）^a
过去1年中家中或四邻有疟疾病例	[13-15, 19]	固定	3.59（2.93,4.40）^a
未受过教育	[3, 6, 13, 20, 23]	随机	1.33（0.88,2.02）^b
年龄≤ 5 岁	[6, 13, 14, 20]	随机	1.67（0.82,3.39）^b