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Application of Structural Biology in Research on Toxoplasma gondii

CHEN Yan-ping1, WEI Dong-dong1, LI Hong-wei2, WEI Yan-bin1, YIN Kun1*   

  1. Shandong Academy of Medical Science, Shandong Institute of Parasitic Diseases, Jining 272033, China；2 Jining No. 1 People’s Hospital, Jining 272100, China
  • Online:2016-12-30 Published:2017-01-10
  • Supported by:

    Supported by the National Natural Science Foundation of China（No. 31300617）, the Promotive Research Fund for Excellent Young- and Middle-aged Scientisit of Shandong Province（No. BS2013SW015）, the Medicine and Health Science Technology Development Plan of Shandong Province（No. WSO370）, and the Open Research Project of Key Laboratory for Parasitic Diseases （No. WSBKTKT201503）.

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Abstract:

Structural biology is a rapidly-developing comprehensive discipline that interprets the atom-level assembling, interaction and movement between molecules. This paper summarizes basic methods in structural biology, with a focus on structure research progress of Toxoplasma gondii rhoptry and calmodulin-like domain protein kinase, to illustrate the application of structural biology in research on important virulence factors and drug targets of T. gondii.

Key words: Structural biology, Toxoplasma gondii, Crystal structure, Rhoptry kinase, Calmudulin-like domain protein kinase