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Research Advances on Toxoplasma gondii Virulence Mediating Factors

XIA Jing,PENG Hong-juan*   

  1. Department of Pathogen Biology,School of Public Health and Tropical Medicine,Southern Medical University;Guangdong Provincial Key Laboratory of Tropical Disease Research,Guangzhou 510515,China
  • Online:2015-08-30 Published:2015-09-10

Abstract:

Toxoplasma gondii strains are grouped into three clonal lineages(TypesⅠ,Ⅱ, and Ⅲ)with different virulence. T. gondii rhoptry proteins ROP18, ROP16, and ROP5 are the major virulence factors, which are secreted into the host cell by T. gondii during invasion and mediate the strain virulence. This paper reviews the research progress of T. gondii virulence mediating factors.

Key words: Toxoplasma gondii, Virulence, Virulence mediating factor