›› 2012, Vol. 30 ›› Issue (4): 13-312-316.

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Research Progress on Peptidoglycan Recognition Proteins of Medical Shells and Molluscs

ZHANG Zong-lu1,2，GUO Yun-hai2，LUO Tai-chang1，Zhang Yi2 *   

  1. 1 School of Life Sciences, Guizhou Normal University, Guiyang 550001, China; 2 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, MOH; WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China
  • Online:2012-08-30 Published:2012-10-26

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Abstract: Peptidoglycan recognition proteins （PGRPs） are highly conserved pattern recognition receptors in evolution, and they can recognize peptidoglycan（PGN） and bacteria that contain PGN in their cell wall component in early immune process of host, then provide signal transduction and activate a series of immune proteins. PGRPs are extensively present in insects, molluscs, echinoderms and vertebrates. Research progress and frontiers on PGRPs gene, type, structure, express localization, function, and evolution in medical molluscs and other snails were briefly reviewed in this article.

Key words: Medical molluscsa, Innate immunity, Peptidoglycan recognition proteins