Abstract: Schistosome infection down-regulates the Th1 cell-mediated autoimmune diseases and Th2 cell-mediated allergic diseases. It was revealed recently that a novel pathogenic T cell subset （Th17） was also involved in the pathogenicity of autoimmune and inflammatory diseases, and schistosome infection was reported to suppress Th17 response in autoimmune diseases. Here we summarize research advances on the effect of schistosome infection on Th1-，Th2-，Th17-mediated autoimmune or allergic diseases，and discuss the possible mechanisms of schistosome-induced suppression.

Key words: Schistosome infection, Autoimmune, Allergic diseases