›› 2006, Vol. 24 ›› Issue (2): 19-152.

• 研究简报 • Previous Articles     Next Articles

Adjuvant Effect of CpG DNA Recombinant Plasmid onAntigen of Cysticercus cellulosae

JING Zhi-zhong;MENG Xue-lian;WANG Pei-ya;DOU Yong-xi;LI Hui;LUO Xue-nong;ZHENG Ya-dong;CAI Xue-peng   

  1. Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences；Gansu Provincial Key Laboratory of Animal Parasitology, Lanzhou 730046, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2006-04-30 Published:2006-04-30

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Abstract: In order to prove the adjuvant effect of CpG DNA recombinant plasmid, the total antibodies and their IgG2a subtype induced by antigen of Cysticercus cellulosae, and content of IL-4 and IFN-γ secreted from splenic cell of mouse immunized were measured. The recombinant plasmids showed an adjuvant effect, and CpG2 was the best adjuvant among the plasmids. It is proved that the CpG DNA possesses a synergistic effect with Al(OH)3 and 206 adjuvant, and is an effective Th1 type adjuvant in mice.

Key words: CpG DNA, Adjuvant effect, Th1 type, Synergistic effect