Abstract: 　Objective To observe the curative effect of Di\n\butyl phthalate\OP emulsion in the treatment of demodicidosis. Methods 447 cases with Demodex infection on face were treated with Di\n\butyl phthalate\OP emulsion. Among them, 30 cases suffering from acne, tetter and pustule were also randomly observed. 20 days after treatment negative conversion rate and the therapeutic effect were evaluated. At the same time, the effect of this solution was compared with that of other three medicaments (FuManLing, 2% metronidazole and 8% metronidazole preparations). In vitro test of mites\|killing, toxicity test in experimental animals and the safety evaluation for local application were also performed. Results Results showed that the negative conversion rate was 92.8%(415/447), effective rate for the cases showing evident face damage was 90.0%(27/30). The result also indicated that the OP emulsion medicament was more effective than other three medicaments (P<0.01). In vitro test showed that this medicament killed all mites within 1 hour. Toxicity test in animals showed that its LD-50 was in safe range. It showed no evident stimulation and hypersensitivity by local use. Conclusion Di\|n\|butyl phthalate\|OP emulsion is promising to be developed as a safe, effective therapeutic medicament on demodicidosis.

Key words: Mite infestations, Demodex, Drug therapy, Di-n-butyl Phthalate