›› 2000, Vol. 18 ›› Issue (3): 4-140.

• 论著 • Previous Articles     Next Articles

ROLE OF TNF-α AND ICAM-1 IN PATHOGENESIS OF CEREBRAL MALARIA

CHE Li mu 1;NIU Yu xin 2;LI Hui zhu 1;CHEN Xiao ning 3   

  1. 1 Department of Parasitology;Capital University of Medical Sciences;Beijing 100054; 2 Department of Genetics;Capital University of Medical Sciences;Beijing 100054; 3 Department of Parasitology,Chengde Medical College,Chengde 067000
  • Received:1900-01-01 Revised:1900-01-01 Online:2000-06-30 Published:2000-06-30

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Abstract: 　Objective] To investigate the role of TNF α and ICAM 1 in the pathogenesis of cerebral malaria. [Methods] Immunohistochemical method and ELISA were employed to examine the expression of ICAM 1 on the brain microvessel endothelium and to detect the production of serum TNF α in P berghei ANKA strain infected CBA/J mice. [Results] Serum TNF αlevels of mice were apparently higher and the ICAM 1 expression was more evident in P berghei ANKA infected CBA/J mice than in control groups. rTNF α ip injection could enhance the development of CM and the expression of ICAM 1 on brain endothelial cells(EC). [Conclusion] Excessive production of TNF α may mediate the expression of ICAM 1 on brain EC and hence cause the development of CM.

Key words: Cerebral malaria(CM), ICAM-1, TNF-α, Plasmodium berghei.