›› 2000, Vol. 18 ›› Issue (3): 2-134.

• 论著 • Previous Articles     Next Articles

HUMAN PARASITE ANTIGEN-SPECIFIC IFN-γ RESPONSE IN SCHISTOSOMITSIS JAPONICA ENDEMIC AREA

SHEN Lei1;WU Hai wei1;ZHANG Zhao song1;Rosemary E Weir2;XIE Zhang wu 3 HU Lin sheng 1;CHEN Shu zhen 1;Martin G Taylor 3;WU Guan ling 1   

  1. 1 Molecular and Immunoparasitology Research Department;Nanjing Medical University;Nanjing Medical University,Nanjing 210029;2Department of Infectious and Tropical Disease,Immunology Unit,London School of Hygiene and Tropical Medicine,London WCIE 7HT;3jiangxi Provincial Insititute of Parasitic Disease,Nanchang 330000
  • Received:1900-01-01 Revised:1900-01-01 Online:2000-06-30 Published:2000-06-30

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Abstract: 　Objective] To explore the characteristics of human schistosome antigen specific IFN γ response in a population in an area endemic for schistosomiasis japonica. [Methods] Three neighboring villages were chosen on Nanshan Island of Poyang Lake. 65 egg negative persons and 64 egg positive ones were selected randomly from the residents aged 14～41 years according to the egg counts by Kato Katz thick smear method. IFN γ was measured in the whole blood culture supernatant after stimulated by the schistosome soluble egg antigen (SEA) and soluble worm antigen preparations (SWAP). Serum isotype restricted antibody was detected by ELISA. [Results] IFN γ levels induced by both SEA and SWAP were increased significantly after praziquantel treatment. The SEA specific IFN γ level of the uninfected group was much higher than that of the reinfected group. A negative correlation between IFN γ level and IgG4 production was found, reflecting that IFN γmight be associated with the resistance to schistosome reinfection. [Conclusion] The changes in IFN γ level might play an important role in association with the resistance to schistosome reinfection.

Key words: Schistosomiasis japonica, reinfection, IFN -γ.