Abstract: 　Objective]To observe the efficacy and safety of co artemether and one of its components benflumetol(two formulations)in the treatment of patients with falciparum malaria [Methods]Adopting double blining,randomization and comparative method, all patients were hospitalized and observed for 28 days after treatment.[Results] Of 150 patients, 51 patients were treated with co artemether group(A), 50 patients were treated with benflumetol tablet group(B),49 patients were freated with benflumetol capsule group(C).The mean fever clearance times for groups A,B and C were 17.1±8.6、34.0±23.2 and 29.4±24.9 hours, respectively;the mean parasite clearance times were 29.7±8.9、51.6±14.1 and 54.7±17.4 hours respectively;the cure rates in 28 days for groups A,B and C were 98.2%, 92.0% and 95.8%,respectively.No apparent side effect was observed.[Conclusion]Co artemether and benflumetol(2 formulations)are effective for the treatment of patients with falciparum malaria but co artemether is more effective than benflumetol(2 formulations)in terms of controlling symptoms and killing parasites.

Key words: Co artemether, artemether benflumetol, falciparum malaria.