EFFECT OF NITROQUINE ON THE MEMBRANE PHOSPHOLIPID OF INTRAERYTHROCYTIC PLASMODIUM YOELII IN VITRO

›› 1999, Vol. 17 ›› Issue (5): 8-284.

• 论著 • Previous Articles Next Articles

EFFECT OF NITROQUINE ON THE MEMBRANE PHOSPHOLIPID OF INTRAERYTHROCYTIC PLASMODIUM YOELII IN VITRO

DENG Shufeng;HU Youmei

Department of Pharmacology;Third Military Medical University;Chongqing 400038

Received:1900-01-01 Revised:1900-01-01 Online:1999-10-30 Published:1999-10-30

Abstract

Abstract: 　AIM: To study the mechanism of antimalarial action of nitroquine.METHODS:Intraerythrocytic P. yoelii was cultured by the method of Trager and Jensen. The amount of [ 3H] ethanolamine incorporation was measured as an index of the phospholipid synthesis.DPH was used as a probe to measure the plasmodial fluorescent polarization.RESULTS:The incorporation of [ 3H] ethanolamine into the P.yoelii infected erthrocytes was markedly inhibited by nitroquine. The plasmodial membrane polarization and viscosity were significantly increased by nitroquine.CONCLUSION: Nitroquine could inhibit the phospholipid synthesis and decrease the membrane fluidity of P.yoelii .

Key words: Plasmodium yoelii, membrane phospholipid, biosynthesis, membrane fluidity

DENGShufeng;HUYoumei . EFFECT OF NITROQUINE ON THE MEMBRANE PHOSPHOLIPID OF INTRAERYTHROCYTIC PLASMODIUM YOELII IN VITRO[J]. , 1999, 17(5): 8-284.

[1]	GUO Shuai, HE Biao, GAO Yuanli, FAN Yongling, ZHU Feng, DING Yan, LIU Taiping, XU Wenyue. Specie-specific analysis of plasmodia infecting rats and mice [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(5): 539-545.
[2]	CHEN Sui-lin, GAO Yuan-li, GUO Shuai, FAN Yong-ling, LIU Tai-ping, XU Wen-yue. Effect and mechanism of high-dose clodronate liposomes treatment on Plasmodium yoelii growth in mice [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(1): 28-35.
[3]	Xiang-yun CHENG, Tai-ping LIU, Sui-lin CHEN, Wen-yue XU. Study on the role of protein kinase 9 in the growth and development of Plasmodium yoelii [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2019, 37(3): 248-253.
[4]	WANG Bing-li*, HUANG Jia-fu, CHEN Fan. In vitro cultivation of ethrythrocytic-stage Plasmodium yoelii [J]. , 2017, 35(4): 21-412-414.
[5]	Guang CHEN, Lei LIU, Fang-fang WANG, Sheng BI, Lan LUO, Ju-xiang SU, Hui-ming ZHANG, Lian-shun CAI, Zi-lin GONG. The regulatory effect of dendritic cells on Th17 cell differentiation and function in mouse infected with Plasmodium yoelii [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2017, 35(1): 8-12.
[6]	CHEN Guang1 ，LIU Lei1，BI Sheng2，LUO Lan2，WANG Fang-fang1，CAI Lian-shun1，SU Ju-xiang1，DAI Yue1. The Ratio of Treg/Th17 Cells from Mice Infected with Plasmodium yoelii* in the Early Stage of Infection [J]. , 2014, 32(6): 4-425-429.
[7]	PAN Yan-Yan, Liu-Jun, Li-Ying, Yan-Juan, Cao-Ya-Meng. L-Arginine Enhances Th1 Immune Response against Plasmodium yoelii 17XL Infection in DBA/2 Mice via Activation of Dendritic Cells [J]. , 2011, 29(4): 2-247-251.
[8]	WANG Yan-Yan, WANG Yang, ZHANG Jian, DUAN Jian-Hua, HUANG Fu-Sheng-. Function of TEP1 Gene during Plasmodium yoelii Infection in Anopheles dirus* [J]. , 2011, 29(1): 6-25-28.
[9]	DINGYan;CHENJi-de;ZHOUTao-li;FUYong;PENGXiao-hong;XUWen-yue*. Inhibition of Plasmodium yoelii Circumsporozoite Protein on the Activation of Nuclear Transcription Factor in Hepatoma Cells Stimulated by TNF-α [J]. , 2009, 27(6): 3-466.
[10]	FUYong;DINGYan;ZHOUTao-li;CHENJi-de;PENGXiao-hong;XUWen-yue. Recombinant Plasmodium yoelii* Expressing Green Fluorescent Protein in Erythrocytic and Mosquito Stages [J]. , 2009, 27(6): 8-491.
[11]	ZHANGJian;XUWen-yue;DUANJian-hua;HUANGFu-sheng. Correlation of Anopheles TEP1* Gene with Melanization Induced by Nitroquine [J]. , 2009, 27(4): 7-325.
[12]	CHENJi-de;ZHOUTao-li;XUWen-yue;DINGYan;HUANGFu-sheng. Inhibition of CpG Oligodeoxynucleotide on the development of pre-erythrocytic stage of Plasmodium* [J]. , 2009, 27(1): 1-5.
[13]	WEIQiu-fen;ZENGLing-e;SUNBao-qing;SHAOChang-ling;WANGFeng-yun;ZHUXin-ping. Effect of Anti-Midgut-Protein-Ingredient Antibodies of Anophelesstephensi on the Oocysts of Plasmodium yoelii [J]. , 2006, 24(6): 9-444.
[14]	XIAOJing-ying;ZHANGDong-mei;CAILian-shun;SHENLu-hui;PANWei-qing. Evaluation of Immunogenicity and Protection Efficacy of the Recombinant Hypoxanthine-Guanine-Xanthine of Plasmodium falciparum in Mice [J]. , 2006, 24(3): 8-195.
[15]	ZHENGWei;LIUJun;MENGDong-ya;HUXiao-fang;CAOYa-ming. Study on Protective Immunity against Infection of Plasmodium yoelii 17XL in DBA/2 Mice [J]. , 2006, 24(1): 4-18.

EFFECT OF NITROQUINE ON THE MEMBRANE PHOSPHOLIPID OF INTRAERYTHROCYTIC PLASMODIUM YOELII IN VITRO

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments