STUDIESON ANTIBODY RESPONSESAND HUMAN SCHISTOSOMIASIS JAPONICA REINFECTION

›› 1997, Vol. 15 ›› Issue (6): 345-348.

STUDIESON ANTIBODY RESPONSESAND HUMAN SCHISTOSOMIASIS JAPONICA REINFECTION

Wu Haiwei¹; Zhang Zhaosong¹; Chen Shuzhen¹; Hu L insheng²; Xie Zhangwu²; Qiu Yingxi²; Wu Yiqin¹; Cao Jianping¹; Su Chuan¹; Zhang Shaoji²; Wu Guanling¹

1 Molecular and Immunoparasitology Laboratory of Nanjing Medical University; Nanjing 210029 2 Jiangxi Provincial Institute for Parasitic Diseases Control, Nanchang 330000

Received:1900-01-01 Revised:1900-01-01 Online:1997-12-28 Published:1997-12-28

Abstract

Abstract: AIM:To explore if there are some antibody responses to be correlated strongly with susceptibility to reinfection of S.japonicum.METHODS:A group of1 96 individuals aged3 - 25 years old in a schistosomiasis endemic area in Nanshan Island of Poyang Lake,who were treated and followed up for identification of reinfection over a 10 - month period during which intense transmission continued in the study area.Serology for testing isotype- restricted antibody responses quantitatively to SEA and WA was performed according to predetermined design in the cohort. RESULTS: After allowing for age and exposure in a logistic regression analysis, IgG4 antibodies were significantly related to susceptibility to reinfection. The individuals with high levels of SEA-specific IgG4 and/or WA-specific IgG4 being 2.83 and 2.40 times were more likely to become reinfected after treatment. CONCLUSION: These findingsmay form a basis for construction of prognostic tests predicting the probability of reinfection and targeting treatment leading to a reduction in drug costs of chemotherapy

Key words: Schistosomiasis japonica, reinfection, isotype- restricted antibodies

WuHaiwei;ZhangZhaosong;ChenShuzhen;HuLinsheng;XieZhangwu;QiuYingxi;WuYiqin;CaoJianping;SuChuan;ZhangShaoji;WuGuanling. STUDIESON ANTIBODY RESPONSESAND HUMAN SCHISTOSOMIASIS JAPONICA REINFECTION[J]. , 1997, 15(6): 345-348.

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STUDIESON ANTIBODY RESPONSESAND HUMAN SCHISTOSOMIASIS JAPONICA REINFECTION

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