Abstract:

AIM:To explore the adjuvant effect of Salmonella typhimurium ribosome preparation (STRP)on adult schistosome antigen (SWA). METHOD:Mice were immunized with STRP+SWA and SWA, respectively.Humoral immunity levels of mice were detected by ELISA and protective immunity of mice were indicated by worm reduction rate. RESULTS:The antibody level of mice immunized with STRP+SWA was significantly higher than that of mice immunized with SWA. After cercariae challenge infection,the worm reduction rate of mice immunized with STRP+SWA was also significantly higher than that of mice immunized with SWA. CONCLUSION:It is suggested that STRP can enhance the humoral response of mouse to SWA and elicit stronger resistance to schistosome cercariae challenge infection.