›› 1996, Vol. 14 ›› Issue (1): 50-53.

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T CELL IMMUNE RESPONSE IN LYMPHATIC FILARIASIS ──ANALYSIS OF PARASITE ANTIGEN INDUCED IL-2 AND IFN-γ PRODUCTION

Chen Zhilin1, Shen Yiping2, Chen Shuzhen2, Zhang Yaojuan2, Guan Xiaohong2, You Lifen3, Yang Weiping1, Wang Zengxian4   

  1. 1 Department of Parasitology, Medical College of Yangzhou University, Yangzhou 225001
    2 Department of Parasitology, Nanjing Medical University, Nanjing 210029
    3 Department of Microbiology, Nanjing Medical University, Nanjing 210029
    4 Department of Parasitology, Anhui Medical University, Hefei 230032
  • Online:1996-02-28 Published:2017-01-02

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Abstract: AIM: To investigate the mechanism of T cell immune response in lymphatic filariasis. METHOD: IL-2 and IFN-γ production in peripheral blood mononuclear cells (PBMC) were examined in vitro from 31 patients with microfilaremia, 32 amicrofilaremic individuals living in bancroftian filariasis endemic area of Anhui Province and 32 controls living in non endemic area. The jirds infected with B.malayi were also examined for IL-2 and IFN-γ production in spleen cells. RESULTS: In each group of human subjects, the production of IL-2 or IFN-γ in response to PHA and ConA did not differ significantly. When B. malayi adult antigen (BmA) -induced IL-2 o -r IFN-γ production was examined, the amicrofilaremic individuals generated significantly more cytokines than did the patients with microfilaremia. In jirds, the results were similar to those in humans. CONCLUSION: These results suggest that there exists T cell hyporesponsiveness to BmA in patients with microfilaremia from bancroftian filariasis endemic area and in jirds  ith microfilaremia of B.malayi.

Key words: Filariasis, microfilaremia, IL-2, IFN-γ