Abstract: Fourteen-34 days after Schistosoma japonzcum-infected mice were injected intraperitoneally with immunoenhancing reagent,Chinese angelica root extract ("425"),the specific antibody (IgG) levels were significantly higher in Group Ⅲ (362.67±162.21-480.00±289.45) than the control group (66.67±39.68-245.33±101.56) in experiment one,and in Gronp Ⅱ(488.00±320.38-768.00±267.38) than the control group (256.00±189.07-394.67±141.06) in experiment two.The egg granulomatous formation were markedly diminished in the injected mice.The ratios of granulomas vs.eggs' mean diameters of Group in of mice were 5.24±1.04-3.95±0.77 and those of the control group were 6.59±1.19-5.29±0.94 in experiment one,those of the group Ⅱ were 3.75±0.71-4.15±0.73 and those of the control group were 4.94±0.81-5.36±0.97 in experiment two.Meantime the egg antigen levels in the injected mice might be lower.This study shows that the control of immunomodulation of granulomatous formation in the hosts injected with immunoenhance reagent "425" can be induced.