Abstract: The present paper reported the extraction of immune RNA (iRNA) from spleen cells of Schistosoma japonicum infected rabbits and the activity of this schistosome iRNA (SiRNA) on transfer of cellular immunity and humoral immunity using macrophage migra-tory inhibition test (MMIT) and Dot-ELISA. The results indicated that specific cellular im-munity could be transferred to normal mice by SiRNA either via in vivo or in vitro sensi-tization. Intraperitoneal inoculation of SiRNA to normal mice may result in production of specific antibodies.