Abstract: 40 patients of falciparum malaria were treated by pyronaridine 800mg jointly with sulfadoxine 1000mg and pyrimethamine 50mg in 2days in endemic area of chloroquine-resistant falciparum malaria on Hainan Island. All the patients in tne combined treatment group became a febrile in an average of 35 ± 12 h and free from a sexual forms in 40 ± 14 h. No recruescence was seen in 39 patients followed-up 28days after medication, the cure rate being 100%. Only mild side effects were observed in the combined treatment group. Besides, 9 patients of falciparum malaria were treated with piperaquine phospbate l500mg alone for 3 days. The average fever subsidence time and parasite clearance time of the group was 39±l5h and 61±27h, respectively. One patient had recrudescence of parasitaemia and two patients showed high resistant level (RIII) to this drug within 28days after medication, the cure rate being 67%.