Abstract: As artemether and artesunate are both soluble in water, they are able to overcome the difficulty of preparation caused by the insolubility of artemisinine. Treatment of 772 cases of various forms of malaria at a total dose of 160-800mg yielded excellent effect with 100% recovery rate, the parasite clearance time being shorter than that of artemisininc and six other antimalarial drugs. In particular, when treating 25 severe cases of malaria, sodium artesunate injection led to satisfactory result, either intramuscularly or intravenously. It is the most effective new antimalarial drug. There were no side-effects, and no significant influences on the function of heart, liver, kidney and other important organs. However, the recrudescence rate of 46.6%(304/652) was relatively high.