Abstract: The experimental effects of 13 combinations of antimalarials against P. berghei "NS"strain were observed with Berenbaum's method (1978). The results showed that combinations of piperaquine + nitroquine in the ratios of 1:1, 1:1/3 and 1/3:1, hydroxy-piperaquine + nitroquine (1:1,1:1/3, and 1/3:1) and pyronaridine + nitroquine (1:1 and 1/3:1) were synergistic.The combinations of piperaquine + pyronaridine (1:1) was additive while piperaquine + mefloquine (1:1) exhibited antagonism (Table 2).