Abstract: The respiratory rates of adult male, female, as well as coupled schistosomes were determined. It was observed that the worms harvested from the liver and mesenteric veins of mouse after treating the experimental animals with fluoroacetamide (CF) did show a considerable reduction in respiration. Once the respiration was inhibited over 50%, hepatic shift of worms occurred. Using succinate as substrate, the effects of ADP, antimycin and oligomycin on the worm mitochondria was investigated, it was shown that ADP stimulated the respiration, whereas antimycin and oligomycin inhibited it.