Abstract: This paper reports on the malaria control measures and their effectiveness in Kaili county and other 11 counties, i. e. Majiang, Huangping, Zhengyuan, Shibing, Tianzhu, Jing-ping, Duyun, Wengan, Fuquan, Longli and Guiding situated in the middle and southeast of Guizhou, with an area of 21 570 km2 and a population of 2.97 million.Prior to antimalarial campaign (1955), the reported malaria cases amounted to 149 605 and the morbidity was 958 per ten thousand. Malaria control programme has been carried out in large scale since 1958 and the morbidity dropped to 5 per ten thousand in 1965. From 1981 onwards, malaria management and surveillance in the final stage of malaria eradication have been undertaken in all the counties and the malaria situation has been greatly changed.At present, leading groups of malaria management and surveillance at county, district and village levels are well organized and the antimalarial infrastructure is well developed. The system of malaria case detection, presumptive treatment, radical treatment, follow-up of malaria case/foci has been set up. From 1981 to 1984, the malarial morbidity was between 0.2-0.03 per ten thousand, the annual blood examination rate was between 7.4-10.2%.