Abstract: Four BALB/c mice and two CFW mice were inoculated subcutaneously with proma-stigotes of Leishmania gerbilli 3.0 ×106/mouse and Leishmania mexicana amazonensis 3.2 × 106/mouse, respectively.1.5 and 5 months after inoculation, the mice were killed for histopathological examination. Leishmania gerbilli in BALB/c mice was confined mainly to the center of phagocytes. On the contrary, Leishmania mexicana amazonensis in CFW mice was chiefly distributed on the edge of phagocytes.Nearly all the cutaneous tissue of the inoculated mice showed congestion, edema and inflammatory cell infiltration, but the average number of neutrophils and fibroblasts in the foci of BALB/c mice was greater than that in the CFW mice, while the average number of lymphocytes in the foci of CFW mice was greater than that in the BALB/c mice (Table 1 and Plates 1-4).