Abstract: The in vitro effect of different sugars and glcoproteins on the invasion of FCC-1/HN strain of P. falciparum merozoite into human erythrocyte is presented.1. Pure human glycophorin A inhibited invasion by 91% at 50μg/ml, and by 100% at 100μg/ml. Hen ovomucoid had 40% inhibitory effect at 100μg/ml.2. Human erythrocytes treated with sialidase or trypsin are less susceptible to merozoite invasion.3. D-glucosamine HC1, sialic and N-acetyl-D-glucosamine all had definitely inhibitory effect on merozoite invasion, however, no synergic effect was detected.4. Concanvalin A had no effect on merozoite invasion at 100μg/ml, while wheat germ agglutinin had a clearly inhibitory effect at the same concentration.