Abstract: Two experimental groups of rabbits, 4 weeks following percutaneous exposure to Schistosoma japonicum cercariae, were injected intramuscularly with 25mg of cortisone acetate (ACT) daily and every other day respectively. All rabbits were autopsied to isolate the eggs from the livers, and pathological sections are prepared 2 weeks after ACT injection, i.e., 6 weeks after exposure. The production of specific schistosomal antibody in rabbits injected with ACT appeared to be markedly suppressed. The formation of schistosome egg granulomas was remarkably diminished while the proportion of reactive schistosome eggs in the livers increased, and the average number of ova in animals injected with ACT daily is 1.64 times that in control rabbits, but the two parametres are less pronounced in rabbits injected with ACT at one day intervals. It is suggested that the immunosuppressive method reported here may be utilized to increase the recovery of schistosome eggs from the livers of infected animals.