Abstract: Primaquine octylamide was administered intramuscularly to rats in single doses of 160, 50 and 16 mg/kg on D7 of gestation. A known teratogen, dexon, at dosages of 1.5, 2 and 3 mg/kg/d×7 was used as positive control. Pregnant rats were sacrificed on D20 and fetuses were subjected to teratological investigation. The results showed that Primaquine octylamide at all dosages exerted no effect on the body-weight of the pregnant rats, the rate of normal fetus, fetal resorption and embryonic growth. Neither altered appearance nor dysmorphosis of viscera and skelaton was noted in all the test groups. It is presumed that when rats were given the maximum dose of primaquine octylamide (= 26×clinical dose) no embryotoxicity was observed under the present experimental conditions.