Abstract: The present report is dealing with the epidemiological features and distribution of E. japonicus in eight counties in the south of Fujian and Raoping County in Guangdong, as well as the results of human and animal experimental infection. It has been shown that this trematode is present in all the 9 counties. The rate of human infection is closely related to the size of fish ponds, the scale of fish raising, the population of dogs and cats, as well as the way of eating fish by the local people. This trematode is widely adapted to various kinds of intermediate and final hosts, being present in all kinds of fishes investigated, especially in Pseudorasbora parva. It not only parasitizes human and mammalian animals, but infects birds as well. This trematode develops rather quickly after infecting its host, its eggs could be found in the host's feces 5-9 days after infection.