Abstract: 25 female cases of mammary filarial tubercles proven by pathological examination in our hospital from 1958-1983 were presented. The main pathological features observed are those of acute endolymphangitis together with granulomatous reaction consisting of fibrinoid necrosis with pronounced infiltration of eosinophils, lymphocytes, mononuclear cells and occasionally epithelioid cells around hecrotic worms. Distension of lymphatics was usually found in the periphery of the lesion.All 25 cases revealed the characteristic pathological features. Dead or calcified worms were found in 21 cases, and microfilariae found in four.Clinically this illness was always misdiagnosed as plasmacyte mastitis, tuberculous mastitis, mammary liponecrosis, mammary cystic hyperplasia, mammary adenocarcinoma and so on. The clinical and pathological differential diagnosis were discussed.