Abstract: This article reports on the result of DDT house residual spraying in the control of A. lesleri anthropophagus and falciparum malaria in Luzhen Commune, Shucheng County, from June to July, 1983. The DDT house residual spraying has good preventive effect on A. lesleri anthropophagus, the biting rate decreased by 99.5% and the life span by 33.5%. But it is not so good for A. hyrcanus var sinensis Wied and its relative density index is higher, i.e. above 100.The transmission rate for malaria in the pilot area in 1983 has obviously decreased, especially for falciparum malaria which has decreased over 85%. This proves that DDT house residual spraying combined with case treatment in an area where A. lesleri anthropophagus is the chief vector is effective in controlling the transmission of falciparum malaria.