Abstract: This paper outlines the history of malaria control in Guangxi Autonomous Region over the past 20 years and gives an account of current epidemic status.High incidence of malaria was restricted in hilly areas and Anopheles minimus was the main vector.Following annual malaria control measures including residual spraying, the incidence of three kifrds of malaria was progressively reduced, the total morbidity of malaria in the region being 3.4 per ten thousand. Qudrtan malaria was rarely seen, and the area epidemic to falciparum malaria was sharply reduced. Howevery in the residual foci of falcipawm malaria, chloroquine-resistant cases are now emergingi Stress should be put on the detection of new cases and the radical treatment. Indoor residual spray must be carried out and chloroquine-resistant malaria must be effectively controlled in the highly epidemic areas.