Abstract: A comparative study on the diagnostic value of immunofluorescence technic(IFCOP) and the conventional COP test using heat-treated and ultrasonicated dry eggs of Schisto soma japonicum as antigens for the diagnosis of schistosomiasis japonica was carried out in areas of different endemicity of schistosomiasis japonica. Results showed no significant difference in sensitivity between two methods in the area of high prevalence. However, in the area of low prevalence IFCOP technic was significantly more sensitive than COP test. Results of tests on sera from 63 patients of schistosomiasis showed that IFCOP and COP were positive in 88.9% and 66.7% respectively. The results indicate that the sensitivity of the COP test is much enhanced by the fluorescent antibody technique in that the small circumoval precipitates can be detected more easily.