Abstract: 28 rabbits, each infected percutaneously with 80 cercariae of Schistosoma japonicum developed pipe-stem fibrosis resembling late human schistosomiasis 4 months later. After a single oral dose of pyquiton 100mg/kg, colchicine was then given to 9 rabbits orally to treat schistosomal hepatic fibrosis in a dosage of 1 mg daily for 3 months. The remaining 19 rabbits were used in different groups of controls, namely, infected control with pyquiton 13, infected control without pyquiton 6, uninfected control 6. Liver biopsies were made before and after colchicine treatment for collagen quantitative determination and pathological observation. The results showed that collagen content was reduced from 43.07±4.25 mg/g wet weight to 15.79±2.66 mg/g wet weight, the thick fibrous bands around intrahepatic portal zone were markedly reduced, and degenerated liver cells mostly recovered. In comparison with amygdalin, hydrocortisone and other Chinese traditional medicines in our previous work, colchicine appears to be a more effective antifibrotic drug.