Abstract: In an area with schistosomiasis basically eradicated, circumoval precipitin test (COPT) and enzyme-linked antigen counterimmunoelectrophoresis (ELACIEP) were used as means of seroepidemiological survey to measure the changes of the specific schis-tosome antibody levels for 5 consecutive years in 219-453 subjects having negative ova or miracidia for stool examinations. 60 cases with a history of previous treatment and 53 persons without therapeutic history were also observed by using these two serological methods. The results showed that both COPT and ELACIEP could reveal kinetic changes of specific schistosome antibody levels in seroepidemiological survey, and be used for evaluation of the efficacy of control. Both COPT and ELACIEP were of value in increasing the detecting rates of patients.