棘球蚴TGF-β/Smad和MAPK信号通路的研究进展

摘要/Abstract

摘要：

由于棘球蚴和宿主的密切接触,在棘球蚴感染过程中,棘球蚴及宿主细胞都可能分泌多种细胞因子,使刺激信号通过细胞表面的受体传递到细胞内,干预宿主的免疫系统,产生免疫耐受从而使棘球蚴能够在宿主体内长期共存。本文就近年来棘球蚴感染过程中转化生长因子-β（TGF-β）/Smad和丝裂原活化蛋白激酶（MAPK）信号通路所起的免疫调节作用作一综述。

关键词: TGF-β/Smad;, 丝裂原活化蛋白激酶, 信号通路, 棘球蚴

Abstract:

Due to the close contact between Echinococcus and the host, both cells of Echinococcus and the host cells secrete various cytokines during infection, which transmit the stimulation signal into the host cells through the cell surface receptors. This process interferes with the immune system of the host and produces immune tolerance, enabling long-term parasitism of Echinococcus within the host. This review summarizes recent findings on the immunoregulatory role of TGF-β/Smad and MAPK signal pathways during Echinococcus infection.

Key words: TGF-β/Smad;, MAPK, Signaling pathway, Echinococcus

中图分类号:

R383.33

王玲玲, 马海梅, 丁剑冰. 棘球蚴TGF-β/Smad和MAPK信号通路的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(5): 516-519.

Ling-ling WANG, Hai-mei MA, Jian-bing DING. Research advances on TGF-β/Smad and MAPK signal pathways in Echinococcus[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2018, 36(5): 516-519.

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