土源性线虫感染对农村学龄前儿童喘息、哮喘和皮肤点刺试验阳性的影响

doi:10.12140/j.issn.1000-7423.2023.03.012

中国寄生虫学与寄生虫病杂志 ›› 2023, Vol. 41 ›› Issue (3): 336-343.doi: 10.12140/j.issn.1000-7423.2023.03.012

土源性线虫感染对农村学龄前儿童喘息、哮喘和皮肤点刺试验阳性的影响

李芳¹(), 王淑芳², 贺朋飞³, 徐淑慧⁴^,^*()

1 运城护理职业学院微生物免疫教研室，山西运城 044000
2 运城护理职业学院预防医学教研室，山西运城 044000
3 运城市中心医院体检科，山西运城 044000
4 海南医学院热带医学院临床检验教研室，海口 570100

收稿日期:2022-10-28 修回日期:2023-03-28 出版日期:2023-06-30 发布日期:2023-06-25
通讯作者: *徐淑慧（1980-），女，博士，副教授，从事病原生物的分子生物学研究，E-mail：17111010072@fudan.edu.cn
作者简介:李芳（1986-），女，硕士，从事常见寄生虫与相关疾病的研究。E-mail：li13028005703@163.com

Effects of soil-transmitted nematode infection on wheezing, asthma, and skin prick test positivities in rural preschool children

LI Fang¹(), WANG Shufang², HE Pengfei³, XU Shuhui⁴^,^*()

1 Department of Microbial Immunology Teaching and Research Office, Yuncheng Nursing College, Yuncheng 044000, Shanxi, China
2 Department of Preventive Medicine, Yuncheng Nursing College, Yuncheng 044000, Shanxi, China
3 Department of Physical Examination, Yuncheng Central Hospital， Yuncheng 044000, Shanxi, China
4 Department of Clinical Laboratory Teaching and Research, Tropical Medical College, Hainan Medical College, Haikou 570100, China

Received:2022-10-28 Revised:2023-03-28 Online:2023-06-30 Published:2023-06-25
Contact: *E-mail: 17111010072@fudan.edu.cn

摘要/Abstract

摘要：

目的探讨农村母亲和儿童土源性线虫感染对学龄前儿童喘息、哮喘和皮肤点刺试验（SPT）阳性的影响。方法收集2020年4月—2021年3月在运城市中心医院门诊进行健康体检的居住在农村地区的学龄前儿童及其母亲。通过问卷收集母亲与儿童基本资料，及关于喘息/哮喘的情况。收集研究对象粪样，采用改良加藤厚涂片法检测土源性线虫感染情况，并进行SPT试验，收集研究对象过敏特应性数据。应用多因素非条件logistic回归分析探讨影响儿童哮喘、喘息、SPT阳性的相关因素。结果本研究中儿童及其母亲各2 014人，母亲的土源性线虫感染率为14.40%（290/2 014），学龄前儿童的土源性线虫感染率为7.99%（161/2 014）。有喘息症状的儿童117例，发生率为5.81%（117/2 014）；哮喘149例，发生率为7.40%（149/2 014）；SPT阳性304例，阳性率为15.09%（304/2 014）。早产儿、母亲有过敏史、家中有人吸烟是儿童喘息的危险因素（P < 0.05，OR > 1）；儿童性别为女、完全母乳喂养是儿童喘息的保护因素（P < 0.05，OR < 1）。母亲有过敏史、家中有人吸烟、家中种植花草是儿童哮喘的危险因素（P < 0.05，OR > 1）；儿童性别为女、完全母乳喂养是儿童哮喘的保护因素（P < 0.05，OR < 1）。母亲有过敏史是儿童SPT阳性的危险因素（P < 0.05，OR > 1），儿童性别为女、儿童有土源性线虫感染、母亲有土源性线虫感染是儿童SPT阳性的保护因素（P < 0.05，OR < 1）。结论母亲和儿童土源性线虫感染可能会降低儿童过敏性疾病的发生。

关键词: 线虫, 儿童, 喘息, 哮喘, SPT阳性

Abstract:

Objective To investigate the effects of soil-transmitted nematode infection of mother and child on wheezing, asthma, and skin prick test (SPT) positive in rural preschool children. Methods Preschool children and their mohers in rural area were enrolled respectively, who underwent physical examination in the Yuncheng Central Hospital outpatient sector from April 2020 to March 2021. Basic information of mothers and children and children’s wheezing/asthma condition were collected through questionnaires. Fecal samples were collected from participants, and examined for soil-transmitted nematode eggs by the Kato-Katz thick smaear method, The SPT test was performed for children to collect allergic and atopic data. Multivariate unconditional logistic regression analysis was used to explore the relevant factors affecting asthma, wheezing, and SPT positivity in children. Results In this study, there were 2 014 children and their mothers each. The infection rate of soil-transmitted nematodes among the mothers was 14.40% (290/2 014), and among the preschool children was 7.99% (161/2 014). There were 117 children had wheezing symptoms, with an occurrence rate of 5.81% (117/2 014); 149 cases had asthma, with an occurrence rate of 7.40% (149/2 014) and 304 cases were positive for SPT, with a positive rate of 15.09% (304/2 014). Premature infants, mothers with a history of allergies, and family members smoking are risk factors for wheezing in children (P < 0.05, OR > 1); female gender and complete breastfeeding are protective factors for wheezing in children (P < 0.05, OR < 1). Mothers with a history of allergies, having someone smoking at home, and planting flowers and plants at home are risk factors for childhood asthma (P < 0.05, OR > 1); female and complete breastfeeding are protective factors for childhood asthma (P < 0.05, OR < 1). Mothers with a history of allergies is a risk factor for SPT positivity in children (P < 0.05, OR > 1), while the gender of the child, presence of soil-transmitted nematode infection in the child, and presence of soil-transmitted nematode infection in the mother are protective factors for SPT positivity in children (P < 0.05, OR < 1). Conclusion Mothers and children infected with soil-transmitted nematode may reduce the occurrence of allergic diseases in children.

Key words: Worm, Children, Wheezing, Asthma, SPT positive

中图分类号:

R383.1

李芳, 王淑芳, 贺朋飞, 徐淑慧. 土源性线虫感染对农村学龄前儿童喘息、哮喘和皮肤点刺试验阳性的影响[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(3): 336-343.

LI Fang, WANG Shufang, HE Pengfei, XU Shuhui. Effects of soil-transmitted nematode infection on wheezing, asthma, and skin prick test positivities in rural preschool children[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2023, 41(3): 336-343.

图/表 6

表1

表2

表3

调查对象中儿童喘息、哮喘、SPT影响因素的单因素分析

特征 Feature	全部（构成比/%） Total (constituent ratio/%)	喘息史（构成比/%） Wheezing history (constituent ratio/%)	哮喘（构成比/%） Asthma history (constituent ratio/%)	SPT阳性（构成比/%） SPT Positive (constituent ratio/%)	χ²（F）	P
母亲 Mothers
分娩年龄/岁 Delivery age/year	25.14 ± 3.82	26.74 ± 3.26	25.99 ± 3.65	26.01 ± 3.74	-2.282	> 0.05
教育年限/年 Education years/year	11.38 ± 3.02	11.25 ± 3.17	11.49 ± 2.98	11.67 ± 2.95	-0.870	> 0.05
过敏史 Allergy history
否 No	1 137（56.45）	54（46.15）	60（40.27）	115（37.83）	2.437	> 0.05
是 Yes	877（43.55）	63（53.85）	89（59.73）	189（62.17）
儿童 Children
性别 Gender
男 Male	1 083（53.77）	84（71.79）	103（69.13）	197（64.80）	2.163	> 0.05
女 Female	931（46.23）	33（28.21）	46（30.87）	107（35.20）
剖宫产 Cesarean section
否 No	1 341（66.58）	85（72.65）	102（68.46）	203（66.78）	1.349	> 0.05
是 Yes	673（33.42）	32（27.35）	47（31.54）	101（33.22）
早产 Premature birth
否 No	1 805（89.62）	86（73.50）	134（89.93）	272（89.47）	20.475	< 0.05
是 Yes	209（10.38）	31（26.50）	15（10.07）	32（10.53）
出生顺序 Birth order	1.94 ± 0.57	2.01 ± 0.32	1.86 ± 0.62	1.99 ± 0.45
出生后母乳喂养 Postnatal breastfeeding
否 No	143（7.10）	0（0.00）	17（11.41）	31（10.20）	34.154	< 0.05
不完全 Incompletely	1 204（59.78）	66（56.41）	56（37.58）	181（59.54）
完全 Completely	667（33.12）	51（43.59）	76（51.01）	92（30.26）
家庭居住面积/m² Household living area/m²	87.24 ± 23.25	90.25 ± 24.16	82.37 ± 28.94	85.19 ± 30.26	-2.267	> 0.05
共同居住人口数/人 No. co residents/person	4.06 ± 1.37	4.84 ± 1.52	4.66 ± 1.28	4.93 ± 1.14	-1.663	> 0.05
家庭宠物数/只 No. family pets/piece	1.06 ± 0.33	1.21 ± 0.40	1.38 ± 0.29	1.25 ± 0.17	-14.500	< 0.05
家中种植花草 Planting flowers and plants at home
否 No	1 197（50.43）	68（58.12）	61（40.94）	183（60.20）	15.647	< 0.05
是 Yes	817（40.57）	49（41.88）	88（59.06）	121（39.80）
饲养大型家畜 Raising large livestock
否 No	761（37.79）	50（42.74）	64（42.95）	117（38.49）	1.125	> 0.05
是 Yes	1 253（62.21）	67（57.26）	85（57.05）	187（61.51）
家中有人吸烟 Someone smoking at home
否 No	917（45.53）	31（26.50）	35（23.49）	143（47.04）	30.438	< 0.05
是 Yes	1 097（54.47）	86（73.50）	114（76.51）	161（52.96）
母亲土源性线虫感染 Mothers infected by soil borne nematodes
否 No	1 724（85.60）	96（82.05）	122（81.88）	282（92.76）	15.386	< 0.05
是 Yes	290（14.40）	21（17.95）	27（18.12）	22（7.24）
儿童土源性线虫感染 Children infected by soil borne nematodes
否 No	1 853（92.01）	106（90.60）	134（89.93）	294（96.71）	10.132	< 0.05
是 Yes	161（7.99）	11（9.40）	15（10.07）	10（3.29）

表3

表4

表5

表6

参考文献 32

[1]	Kowalczyk K, K?ape? T. Contamination of soil with eggs of geohelminths Ascaris spp., Trichuris spp., Toxocara spp. in Poland-potential source of health risk in farmers[J]. Ann Parasitol, 2020, 66(4): 433-440.
[2]	Wu YF, Wei F, Chen QH, et al. Analysis of monitoring results of soil-borne nematode disease in Jianhe County of Guizhou in 2016[J]. Chin J Endem, 2018, 37(12): 1002-1005. (in Chinese)
	(吴运凤, 卫芳, 陈清花, 等. 2016年贵州省剑河县土源性线虫病监测结果分析[J]. 中华地方病学杂志, 2018, 37(12): 1002-1005.)
[3]	Aemiro A, Menkir S, Tegen D, et al. Prevalence of soil-transmitted helminthes and associated risk factors among people of Ethiopia: a systematic review and meta-analysis[J]. Infect Dis (Auckl), 2022, 15: 11786337211055437.
[4]	Brummaier T, Tun NW, Min AM, et al. Burden of soil-transmitted helminth infection in pregnant refugees and migrants on the Thailand-Myanmar border: results from a retrospective cohort[J]. PLoS Negl Trop Dis, 2021, 15(3): e0009219.
[5]	Meng S, Sun C, Ye RX, et al. Evaluation of the effectiveness of prevention and control of soil borne nematode infections in children in underdeveloped rural areas of the Yi ethnic group in Liangshan Prefecture, Sichuan Province based on a dual difference model[J]. Chin J Parasitol Parasit Dis, 2019, 37(2): 183-188, 195. (in Chinese)
	(孟莎, 孙畅, 叶睿雪, 等. 基于双重差分模型对四川省凉山州彝族欠发达农村地区儿童土源性线虫感染防治效果评价[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(2): 183-188, 195.)
[6]	Hotez PJ. Toxocariasis: a neglected infection for the Anthropocene epoch[J]. Adv Parasitol. 2020, 109: 879-883.
[7]	Jin W, Guo JD, Zhang SQ, et al. Distribution and risk factors of soil-transmitted nematode diseases in Anhui Province[J]. Chin J Dis Control Prev, 2018, 22(10): 1041-1045. (in Chinese)
	(金伟, 郭见多, 张世清, 等. 安徽省土源性线虫病流行特征及相关因素分析[J]. 中华疾病控制杂志, 2018, 22(10): 1041-1045.)
[8]	Hu B, Chen GZ, Huang P. Epidemiology related to soil-borne nematode disease in Danzhou City, Hainan Province[J]. Chin J Epidemiol, 2018, 39(4): 474-477. (in Chinese)
	(胡波, 陈国志, 黄平. 海南省儋州市2013—2016年人群感染土源性线虫状况分析[J]. 中华流行病学杂志, 2018, 39(4): 474-477.)
[9]	Zhang YN, Li GH, Liu Y, et al. Report on surveillance of soil-transmittednematodeinfections in Shanxi Province in 2011[J]. Int J Med Parasit Dis, 2013(1): 25-28. (in Chinese)
	(张玉农, 李国华, 刘元, 等. 山西省2011年土源性线虫病监测报告[J]. 国际医学寄生虫病杂志, 2013(1): 25-28.)
[10]	Takeuchi H, Alfazal Khan M, Zaman K, et al. Classification of wheezing children in rural Bangladesh by intensity of Ascaris infection, total and specific IgE levels, history of pneumonia, and other risk factors[J]. J Immunol Res, 2019, 2019: 4236825.
[11]	Chico ME, Vaca MG, Rodriguez A, et al. Soil-transmitted helminth parasites and allergy: observations from Ecuador[J]. Parasite Immunol, 2019, 41(6): e12590.
[12]	Cooper PJ, Chico ME, Vaca MG, et al. Effect of early-life geohelminth infections on the development of wheezing at 5 years of age[J]. Am J Respir Crit Care Med, 2018, 197(3): 364-372.
[13]	Cooper PJ, Chis Ster I, Chico ME, et al. Impact of early life geohelminths on wheeze, asthma and atopy in Ecuadorian children at 8 years[J]. Allergy, 2021, 76(9): 2765-2775.
[14]	Sousa-Santos ACAF, Moreno AS, Santos ABR, et al. Parasite infections, allergy and asthma: a role for tropomyosin in promoting type 2 immune responses[J]. Int Arch Allergy Immunol, 2020, 181(3): 221-227.
[15]	Mohammadzadeh I, Rostami A, Darvish S, et al. Exposure to Ascaris lumbricoides infection and risk of childhood asthma in north of Iran[J]. Infection, 2019, 47(6): 991-999.
[16]	Martin I, Kaisar MMM, Wiria AE, et al. The effect of gut microbiome composition on human immune responses: an exploration of interference by helminth infections[J]. Front Genet, 2019, 10: 1028.
[17]	Zakzuk J, Casadiego S, Mercado A, et al. Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community[J]. Acta Trop, 2018, 187: 1-4.
[18]	Mohammed SH, Jabbr AS, Ibrahim NK. Impact of parasitic infection with Ascaris lumbricoides on pulmonary function tests in asthmatic and non-asthmatic children[J]. Respir Med Case Rep, 2021, 34: 101552.
[19]	Dos S Jesus T, Dos S Costa R, Alcantara-Neves NM, et al. Variants in the CYSLTR2 are associated with asthma, atopy markers and helminths infections in the Brazilian population[J]. Prostaglandins Leukot Essent Fatty Acids, 2019, 145: 15-22.
[20]	Wang J, Huang Y, Zhang XL, et al. An analysis of skin prick test reactivity to dustmite in overweight and normal weight children with allergic asthma before and after specific immunotherapy[J]. Chin J Contemp Pediatr, 2016, 18(4): 329-334. (in Chinese)
	(王健, 黄英, 张学莉, 等. 超重与正常体重过敏性哮喘儿童特异性免疫治疗前后尘螨皮肤点刺试验强度分析[J]. 中国当代儿科杂志, 2016, 18(4): 329-334.)
[21]	Abera D, Wordofa M, Mesfin A, et al. Intestinal helminthic infection and allergic disorders among school children enrolled in mass deworming program, Sululta, Ethiopia[J]. Allergy Asthma Clin Immunol, 2021, 17(1): 43.
[22]	Caraballo L, Zakzuk J, Acevedo N. Helminth-derived cystatins: the immunomodulatory properties of an Ascaris lumbricoides cystatin[J]. Parasitology, 2021: 1-13.
[23]	Pitrez PM, Gualdi LP, Barbosa GL, et al. Effect of different helminth extracts on the development of asthma in mice: the influence of early-life exposure and the role of IL-10 response[J]. Exp Parasitol, 2015, 156: 95-103.
[24]	Alcantara-Neves NM, Veiga RV, Ponte JCM, et al. Dissociation between skin test reactivity and anti-aeroallergen IgE: determinants among urban Brazilian children[J]. PLoS One, 2017, 12(3): e0174089.
[25]	Sanya RE, Nkurunungi G, Hoek Spaans R, et al. The impact of intensive versus standard anthelminthic treatment on allergy-related outcomes, helminth infection intensity, and helminth-related morbidity in lake Victoria fishing communities, Uganda: results from the LaVIISWA cluster-randomized trial[J]. Clin Infect Dis, 2019, 68(10): 1665-1674.
[26]	Mkhize-Kwitshana ZL, Naidoo P, Nkwanyana NM, et al. Concurrent allergy and helminthiasis in underprivileged urban South African adults previously residing in rural areas[J]. Parasite Immunol, 2022, 44(4/5): e12913.
[27]	Brandt O, Wegenstein B, Müller I, et al. Association between allergic sensitization and intestinal parasite infection in schoolchildren in Gqeberha, South Africa[J]. Clin Exp Allergy, 2022, 52(5): 670-683.
[28]	Staal SL, Hogendoorn SKL, Voets SA, et al. Prevalence of atopy following mass drug administration with albendazole: a study in school children on Flores Island, Indonesia[J]. Int Arch Allergy Immunol, 2018, 177(3): 192-198.
[29]	Beckmann J, Lang C, du Randt R, et al. Prevalence of stunting and relationship between stunting and associated risk factors with academic achievement and cognitive function: a cross-sectional study with South African primary school children[J]. Int J Environ Res Public Health, 2021, 18(8): 4218.
[30]	Lim-Leroy A, Chua TH. Prevalence and risk factors of geohelminthiasis among the rural village children in Kota Marudu, Sabah, Malaysia[J]. PLoS One, 2020, 15(9): e0239680.
[31]	Sadowska N, Tomza-Marciniak A, Juszczak M. Soil contamination with geohelminths in children’s play areas in Szczecin, Poland[J]. Ann Parasitol, 2019, 65(1): 65-70.
[32]	Khan W, Khatoon N, Arshad S, et al. Evaluation of vegetables grown in dry mountainous regions for soil transmitted helminths contamination[J]. Braz J Biol, 2021, 82: e238953.

因素 Factor	赋值 Assignment	因素 Factor	赋值 Assignment
母亲年龄/岁 Age of mothers/year	≤ 30 = 0，≥ 31 = 1	母亲文化程度 Education level of mothers	中学及以下 = 0，大专及以上 = 1 Middle school and below = 0, College and above = 1
儿童年龄/岁 Age of children/year	3~5 = 0，6~8 = 1	儿童性别 Gender of children	男 = 0，女 = 1 Male = 0, Female = 1
母亲分娩年龄/岁 Delivery age of mothers/year	< 24 = 0，≥ 24 = 1	母亲过敏史 Allergy history of mothers	否 = 0，是 = 1 No = 0, Yes = 1
剖宫产 Cesarean section	否 = 0，是 = 1 No = 0, Yes = 1	早产 Premature birth	否 = 0，是 = 1 No = 0, Yes = 1
出生顺序 Birth order	1 = 0，≥ 2 = 1	完全母乳喂养 Complete breastfeeding	否 = 0，是 = 1 No = 0, Yes = 1
家庭居住面积/m² Household living area/m²	< 50 = 0，≥ 50 = 1	家庭宠物数目/只 No. family pets/piece	≤ 2 = 0，≥ 2 = 1
家中种植花草 Planting flowers and plants at home	否 = 0，是 = 1 No = 0, Yes = 1	饲养大型家畜 Raising large livestock	否 = 0，是 = 1 No = 0, Yes = 1
母亲土源性线虫感染 Mothers infected with soil borne nematodes	否 = 0，是 = 1 No = 0, Yes = 1	儿童土源性线虫感染Children infected by soil borne nematodes	否 = 0，是 = 1 No = 0, Yes = 1
家中有人吸烟 Someone smoking at home	否 = 0，是 = 1 No = 0, Yes = 1	儿童有喘息史 Wheezing history of children	否 = 0，是 = 1 No = 0, Yes = 1
儿童有哮喘史 Asthma history of children	否 = 0，是 = 1 No = 0, Yes = 1	儿童SPT阳性 SPT positive in children	否 = 0，是 = 1 No = 0, Yes = 1

特征 Feature	检查人数 No. examined	鞭虫 Trichuris trichura		钩虫 Hookworm		蛔虫 Ascaris lumbricoides		合计 Total
特征 Feature	检查人数 No. examined	感染人数 No. infected	感染率/% Infection rate/%	感染人数 No. infected	感染率/% Infection rate/%	感染人数 No. infected	感染率/% Infection rate/%	感染人数 No. infected	感染率/% Infection rate/%
母亲 Mothers
年龄/岁 Age/Year
18~29	927	10	1.08	5	0.54	57	6.15	72	7.77
30~35	648	9	1.39	7	1.08	69	10.65	85	13.12
≥ 36	439	22	5.01	11	2.51	100	22.78	133	30.3
文化程度 Education level
小学及以下 Primary school and below	1 203	27	2.24	16	1.33	150	12.47	193	16.04
中学 Middle school	655	13	1.98	7	1.07	69	10.53	89	13.59
大专及以上 College and above	156	1	0.64	0	0	7	4.45	8	5.13
儿童 Children
年龄/岁 Age/Year
3	626	7	1.12	4	0.64	37	5.91	56	8.95
4	894	9	1.01	5	0.56	65	7.27	52	5.82
5~6	494	6	1.21	5	1.01	23	4.66	53	10.73
性别 Gender
男 Male	1 193	8	0.67	6	0.5	73	6.12	87	7.29
女 Female	821	14	1.71	8	0.97	52	6.33	74	9.01

因素 Factor	回归系数 Regression coefficient	标准误差 Standard error	χ²	P	OR	OR 95%CI
常数 Constant	0.100	0.048	4.344	< 0.05	-	-
早产儿 Premature	0.691	0.192	12.907	< 0.05	1.996	1.369~2.909
儿童性别 Gender of children	-0.459	0.201	5.230	< 0.05	0.632	0.426~0.936
母亲有过敏史 Allergy history of mothers	0.768	0.204	14.132	< 0.05	2.156	1.444~3.217
完全母乳喂养 Complete breastfeeding	-0.875	0.300	8.528	< 0.05	0.417	0.232~0.750
家中有人吸烟 Someone smoking at home	0.700	0.288	5.905	< 0.05	2.014	1.145~3.542

因素 Factor	回归系数 Regression coefficient	标准误差 Standard error	χ²	P	OR	OR 95%CI
常数 Constant	-0.044	0.023	3.552	> 0.05	-	-
儿童性别 Gender of children	-0.219	0.091	5.802	< 0.05	0.803	0.672~0.960
母亲有过敏史 Allergy history of mothers	0.767	0.215	12.716	< 0.05	2.153	1.413~3.282
完全母乳喂养 Complete breastfeeding	-0.475	0.177	7.185	< 0.05	0.622	0.439~0.880
家中有人吸烟 Someone smoking at home	0.628	0.168	13.945	< 0.05	1.873	1.348~2.605
家中种植花草 Planting flowers and plants at home	0.461	0.205	5.073	< 0.05	1.585	1.062~2.368

因素 Factor	回归系数 Regression coefficient	标准误差 Standard error	χ²	P	OR	OR 95%CI
常数 Constant	-0.076	0.037	4.156	< 0.05	-	-
儿童性别 Gender of children	-0.282	0.127	4.929	< 0.05	0.754	0.588~0.967
母亲有过敏史 Allergy history of mothers	0.249	0.096	6.788	< 0.05	1.283	1.064~1.547
儿童土源性线虫感染 Children infected by soil borne nematodes	-0.337	0.139	5.873	< 0.05	0.714	0.544~0.938
母亲土源性线虫感染Mothers infected by soil borne nematodes	-0.464	0.120	14.846	< 0.05	0.629	0.497~0.796

土源性线虫感染对农村学龄前儿童喘息、哮喘和皮肤点刺试验阳性的影响

Effects of soil-transmitted nematode infection on wheezing, asthma, and skin prick test positivities in rural preschool children

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