上海崇明血蜱原虫感染情况及其系统进化分析

doi:10.12140/j.issn.1000-7423.2026.01.011

中国寄生虫学与寄生虫病杂志 ›› 2026, Vol. 44 ›› Issue (1): 72-78.doi: 10.12140/j.issn.1000-7423.2026.01.011

上海崇明血蜱原虫感染情况及其系统进化分析

沈永(), 李元元, 王子怡, 杨丽敏, 黄立荣, 李中秋, 韩青池, 张仪, 郭云海, 刘琴^*()()

中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心），传染病溯源预警与智能决策全国重点实验室，国家卫生健康委员会寄生虫病原与媒介生物学重点实验室，世界卫生组织热带病合作中心，科技部国家级热带病国际联合研究中心，上海 200025

收稿日期:2025-11-11 修回日期:2026-02-05 出版日期:2026-02-28 发布日期:2026-02-26
通讯作者: * 刘琴（ORCID：0000-0003-3172-5218），女，博士，研究员，主要从事医学媒介生物学研究。E-mail：liuqin@nipd.chinacdc.cn
作者简介:沈永，女，硕士研究生，主要从事医学媒介生物学研究。E-mail：shenyong200107@163.com
基金资助:
上海市加强公共卫生体系建设三年行动计划（2023—2025年）(GWVI-11.1-12);上海市卫生健康委员会临床研究专项(202140215)

Prevalence and phylogenetic analysis of protozoan in Haemaphysalis ticks from Chongming, Shanghai

SHEN Yong(), LI Yuanyuan, WANG Ziyi, YANG Limin, HUANG Lirong, LI Zhongqiu, HAN Qingchi, ZHANG Yi, GUO Yunhai, LIU Qin^*()()

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Centerfor Tropical Diseases Research; National Key Laboratory of Intelligent Tracking and Forecasting forInfectious Diseases; NHC Key Laboratory on Parasite and Vector Biology; WHO Collaborating Centre forTropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science andTechnology, Shanghai 200025, China

Received:2025-11-11 Revised:2026-02-05 Online:2026-02-28 Published:2026-02-26
Contact: *E-mail: liuqin@nipd.chinacdc.cn
Supported by:
Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai (2023-2025)(GWVI-11.1-12);Clinical Research Special Project of Shanghai Municipal Health Commission(202140215)

摘要/Abstract

摘要：

目的探索崇明地区蜱中常见顶复门原虫的感染情况和遗传进化特征，为崇明地区蜱传性疾病的防控工作提供参考。方法 2023年7—9月，使用布旗法在上海崇明采集游离蜱，形态学鉴定后按蜱种和生长阶段分装（同种成蜱1只/份、若蜱5只/份、幼蜱10只/份），提取蜱基因组DNA，PCR扩增细胞色素c氧化酶亚基1（cox1）基因和16S rDNA基因鉴定蜱种。巢式PCR扩增巴贝虫/泰勒虫18S rRNA基因短片段（约400 bp），阳性样品进一步扩增18S rRNA基因长片段（约1 600 bp）。巢式PCR阳性产物测序后进行BLAST比对，使用MEGA 11软件计算不同样品的遗传距离并构建系统进化树。原虫检出率的比较使用卡方检验。结果共采集游离蜱622只，其中长角血蜱255只、褐黄血蜱367只。长角血蜱分装为83份样品（成蜱55份、若蜱16份、幼蜱12份），褐黄血蜱分装为43份样品（成蜱2份、若蜱9份、幼蜱32份）。18S rRNA基因短片段扩增获得17份阳性样品，其中长角血蜱的阳性样品16份（成蜱9份、若蜱7份），褐黄血蜱的阳性样品1份（成蜱）。17份阳性样品均扩增出18S rRNA基因长片段，测序序列的登录号分别为PX453257~PX453273。BLAST比对结果表明：1条序列与巴贝虫的18S rRNA基因序列（MK930513）一致性为99.52%，7条序列与新型原虫Colpodella的18S rRNA基因序列一致性为91.53%~99.94%，9条序列与肾形虫的18S rRNA基因序列一致性为95.66%~99.36%。遗传距离分析结果表明，7条Colpodella序列间的遗传距离为0.003~0.147，9条肾形虫序列间的遗传距离为0.009~0.060，种内序列保守性较高；Colpodella与肾形虫之间的遗传距离为0.124~0.221，不同属之间遗传距离较大。系统进化树结果显示，肾形虫和Colpodella聚为一大分支，巴贝虫与泰勒虫聚为另一大分支。长角血蜱的巴贝虫、Colpodella、肾形虫检出率和原虫总检出率分别为1.20%（1/83）、8.43%（7/83）、9.64%（8/83）和19.28%（16/83），褐黄血蜱的巴贝虫、Colpodella、肾形虫检出率和原虫总检出率分别为0（0/43）、0（0/43）、2.33%（1/43）和2.33%（1/43），长角血蜱的原虫总检出率高于褐黄血蜱（χ² = 6.29，P < 0.05）。结论崇明地区游离蜱中存在巴贝虫、肾形虫和新型原虫Colpodella感染，有引发蜱传性疾病的潜在风险。

关键词: 血蜱, 巴贝虫, 肾形虫, Colpodella属, 新型原虫, 崇明

Abstract:

Objective To investigate the prevalence and genetic characteristics of common Apicomplexan protozoan in ticks collected from Chongming, Shanghai, so as to provide insights into management of tick-borne diseases in Chongming area. Methods Free-living ticks were collected using the flagging method in Chongming, Shanghai, from July to September 2023. Following morphological identification, ticks were pooled according to species and developmental stage (one adult per pool, five nymphs per pool, or ten larvae per pool), and genomic DNA was extracted from each pool. Tick species were molecularly identified by PCR amplification of the cytochrome c oxidase subunit 1 (cox1) gene and 16S rDNA gene. The short fragment of the Babesia/Theileria 18S rRNA gene (approximately 400 bp in length) was amplified using nested PCR assay, and positive samples were further subjected to amplification of the long fragment of the 18S rRNA gene (approximately 1 600 bp in length), and positive nested PCR products were sequenced, followed by sequence alignment with BLAST. Genetic distances were calculated among different samples using the software MEGA 11 and phylogenetic trees were created. Differences in the detection of protozoan were tested for statistical significance with chi-square test. Results A total of 622 free-living ticks were collected, including 255 Haemaphysalis longicornis and 367 H. flava. H. longicornis ticks were divided into 83 pools (55 adult pools, 16 nymph pools and 12 larval pools), and H. flava were divided into 43 pools (2 adult pools, 9 nymph pools and 32 larval pools). Nested PCR amplification of the short fragment of the 18S rRNA gene yielded 17 positive pools, including 16 H. longicornis pools (9 adult pools and 7 nymph pools) and one H. flava pool (adult pool). and the long fragment of the 18S rRNA gene was successfully amplified from all 17 positive pools, with sequences deposited under accession numbers of PX453257 to PX453273. BLAST alignments revealed that one gene sequence showed 99.52% identity with the Babesia 18S rRNA gene sequence (MK930513), 7 gene sequences showed 91.53% to 99.94% identity with the 18S rRNA gene sequences of the novel protozoan Colpodella, and 9 gene sequences showed 95.66% to 99.36% identity with the Colpoda 18S rRNA gene sequences. Genetic distance analysis indicated high intraspecific sequence conservation, with genetic distances ranging from 0.003 to 0.147 among 7 Colpodella gene sequences and from 0.009 to 0.060 among 9 Colpoda gene sequences, and the genetic distance between Colpodella and Colpoda ranged from 0.124 to 0.221, indicating substantial interspecific divergence. Phylogenetic analysis revealed that Colpoda and Colpodella were clustered into a large clade, and Babesia and Theileria were clustered into another large clade. The detection rates of Babesia, Colpodella, Colpoda, and protozoan were 1.20% (1/83), 8.43% (7/83), 9.64% (8/83), and 19.28% (16/83) in H. longicornis, and 0 (0/43), 0 (0/43), 2.33% (1/43), and 2.33% (1/43) in H. flava, respectively. The overall detection of protozoan was significantly higher in H. longicornis than in H. flava (χ² = 6.29, P < 0.05). Conclusion There were Babesia, Colpoda, and novel protozoan Colpodella infections in free-living ticks collected from Chongming area, indicating a potential risk of tick-borne diseases.

Key words: Haemaphysalis, Babesia, Colpoda, Colpodella, Novel protozoan, Chongming

中图分类号:

R382

沈永, 李元元, 王子怡, 杨丽敏, 黄立荣, 李中秋, 韩青池, 张仪, 郭云海, 刘琴. 上海崇明血蜱原虫感染情况及其系统进化分析[J]. 中国寄生虫学与寄生虫病杂志, 2026, 44(1): 72-78.

SHEN Yong, LI Yuanyuan, WANG Ziyi, YANG Limin, HUANG Lirong, LI Zhongqiu, HAN Qingchi, ZHANG Yi, GUO Yunhai, LIU Qin. Prevalence and phylogenetic analysis of protozoan in Haemaphysalis ticks from Chongming, Shanghai[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2026, 44(1): 72-78.

图/表 5

表1

表2

表3

图1

表4

参考文献 25

[1]	Tian D, Ye RZ, Li YY, et al. Virome specific to tick genus with distinct ecogeographical distribution[J]. Microbiome, 2025, 13(1): 57.
[2]	Madison-Antenucci S, Kramer LD, Gebhardt LL, et al. Emerging tick-borne diseases[J]. Clin Microbiol Rev, 2020, 33(2): e00083-e00018.
[3]	Qi Y, Wang JH, Lu NH, et al. Potential novel Colpodella spp. (Phylum Api complexa) and high prevalence of Colpodella spp. in goat-attached Haemaphysalis longicornis ticks in Shandong Province, China[J]. Ticks Tick Borne Dis, 2024, 15(3): 102328.
[4]	Soliman AM, Mahmoud HYAH, Hifumi T, et al. Discovery of Colpodella spp. in ticks (Hyalomma dromedarii) infesting camels in southern Egypt[J]. Ticks Tick Borne Dis, 2024, 15(5): 102352.
[5]	Soliman AM, Mahmoud HYAH, Amer MM, et al. First detection of Colpodella spp. in Rhipicephalus annulatus and molecular characterization of piroplasmids in southern Egypt[J]. Front Vet Sci, 2025, 12: 1617204.
[6]	Jimale KA, Bezerra-Santos MA, Mendoza-Roldan JA, et al. Molecular detection of Colpodella sp. and other tick-borne pathogens in ticks of ruminants, Italy[J]. Acta Trop, 2024, 257: 107306.
[7]	魏子昕, 方圆, 张仪. 上海市蜱种类、分布及其携带病原[J]. 中国媒介生物学及控制杂志, 2022, 33(1): 120-124.
	Wei ZX, Fang Y, Zhang Y. Ticks species, distribution and pathogens in Shanghai, China[J]. Chin J Vector Biol Control, 2022, 33(1): 120-124. (in Chinese)
[8]	邓国藩, 姜在阶. 《中国经济昆虫志》第三十九册, 蜱螨亚纲: 硬蜱科[J]. 昆虫知识, 1992, 29(1): 52.
	Deng GF, Jiang ZJ. Economic insect fauna of China fasc 39, Acari:Ixodidae[J]. Entomol Knowl, 1992, 29(1): 52. (in Chinese)
[9]	Folmer O, Black M, Hoeh W, et al. DNA primers for amplification of mitochondrial cytochrome c oxidase subunit Ⅰ from diverse metazoan invertebrates[J]. Mol Mar Biol Biotechnol, 1994, 3(5): 294-299.
[10]	刘琴, 张仪, 方圆, 等. 基于16S rDNA和COⅠ基因的3种血蜱分子生物学鉴定[J]. 国际医学寄生虫病杂志, 2015, 42(3): 146-151.
	Liu Q, Zhang Y, Fang Y, et al. Identification of Haemaphysalis longicornis, H. flava and H. campanulata based on molecular markers of 16S rDNA and COⅠ gene[J]. Int J Med Parasit Dis, 2015, 42(3): 146-151. (in Chinese)
[11]	李素华, 赵玉玲, 高丽君, 等. 河南省信阳市发热伴血小板减少患者中巴贝虫感染的分子流行特征分析[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(1): 66-69.
	Li SH, Zhao YL, Gao LJ, et al. Analysis of molecular epidemiology of babesiosis in patients having fever and thrombocytopenia in Xinyang City, Henan Province[J]. Chin J Parasitol Parasit Dis, 2019, 37(1): 66-69. (in Chinese)
[12]	Zeng WB, Li ZQ, Jiang TG, et al. Identification of bacterial communities and tick-borne pathogens in Haemaphysalis spp. collected from Shanghai, China[J]. Trop Med Infect Dis, 2022, 7(12): 413.
[13]	Waked R, Krause PJ. Human babesiosis[J]. Infect Dis Clin North Am, 2022, 36(3): 655-670.
[14]	Krause PJ. Human babesiosis[J]. Int J Parasitol, 2019, 49(2): 165-174.
[15]	Hong SH, Kim SY, Song BG, et al. Detection and characterization of an emerging type of Babesia sp. similar to Babesia motasi for the first case of human babesiosis and ticks in Korea[J]. Emerg Microbes Infect, 2019, 8(1): 869-878.
[16]	Kim JY, Cho SH, Joo HN, et al. First case of human babesiosis in Korea: detection and characterization of a novel type of Babesia sp. (KO1) similar to ovine Babesia[J]. J Clin Microbiol, 2007, 45(6): 2084-2087.
[17]	Chiu HC, Sun XS, Bao YL, et al. Molecular identification of Colpodella sp. of South China tiger Panthera tigris amoyensis (Hilzheimer) in the Meihua Mountains, Fujian, China[J]. Folia Parasitol, 2022, 69.
[18]	Hasapis KA, Charalambidou I, Phanis CO, et al. First detection and molecular characterization of Colpodella in goats, foxes, and birds[J]. Acta Parasitol, 2025, 70(1): 22.
[19]	Zhao YL, Cao ZX, Li SZ, et al. Biological characteristics and epidemiological insights into the zoonotic potential of Colpodella spp. A scoping review[J]. Infect Dis Poverty, 2025, 14: 91.
[20]	Neculicioiu VS, Colosi IA, Toc DA, et al. When a ciliate meets a flagellate: a rare case of Colpoda spp. and Colpodella spp. isolated from the urine of a human patient case report and brief review of literature[J]. Biology, 2021, 10(6): 476.
[21]	Li BL, Song YM, Hao TT, et al. Insights into the phylogeny of the ciliate of class Colpodea based on multigene data[J]. Ecol Evol, 2022, 12(10): e9380.
[22]	Costache C, Bursa?iu S, Filipa? C, et al. A case of ciliate protozoa Colpoda spp. (Ciliata:Colpodidae) detected in human urine[J]. Iran J Parasitol, 2011, 6(4): 99-104.
[23]	Bouchoucha I, Aziz A, Hoffart L, et al. Repertoire of free-living protozoa in contact lens solutions[J]. BMC Ophthalmol, 2016, 16(1): 191.
[24]	Jiang JF, Jiang RR, Chang QC, et al. Potential novel tick-borne Colpodella species parasite infection in patient with neurological symptoms[J]. PLoS Negl Trop Dis, 2018, 12(8): e0006546.
[25]	Yuan CL, Keeling PJ, Krause PJ, et al. Colpodella spp.-like parasite infection in woman, China[J]. Emerg Infect Dis, 2012, 18(1): 125-127.

引物名称 Primer name	引物序列（5′→3′） Primer sequence (5′→3′)	产物大小/bp Product size/bp
cox1	F：TAAACTTCAGGGTGACCAAAAAATCA	700
	R：GGTCAACAAATCATAAAGATATTGG
16S rDNA	F：CTGCTCAATGATTTTTTAAATTGCTGTGG	400
	R：CCGGTCTGAACTCAGATCAAGT
18S rRNA基因短片段 18S rRNA short fragment	F1：AATTACCCAATCCTGACACAGG	400
18S rRNA基因短片段 18S rRNA short fragment	R1：TTTCGCAGTAGTTCGTCTTTAACA
	F2：GACACAGGGAGGTAGTGACAAGA
	R2：CCCAACTGCTCCTATTAACCATTAC
18S rRNA基因长片段 18S rRNA long fragment	F1：GCCAGTAGTCATATGCTTGTGTTA	1 600
18S rRNA基因长片段 18S rRNA long fragment	R1：CTCCTTCCTYTAAGTGATAAGGTTCAC
	F2：CCATGCATGTCTWAGTAYAARCTTTTA
	R2：CCTYTAAGTGATAAGGTTCACAAAACTT

特征 Fature	采集蜱数 No. ticks collected
特征 Fature	长角血蜱 H. longicornis	褐黄血蜱 H. flava	合计 Total
采集环境 Sampling environment
居民区 Residential area	0	20	20
公园 Park	194	347	541
跑马场 Racecourse	61	0	61
生长阶段 Growth stage
幼蜱 Larva	120	320	440
若蜱 Nymph	80	45	125
成蜱 Adult	55	2	57
合计 Total	255	367	622

序列登录号 Sequence account numbers	PX453257	PX453263	PX453266	PX453267	PX453268	PX453270	PX453272	PX453258	PX453259	PX453261	PX453262	PX453264	PX453265	PX453269	PX453271	NJ-T-37	2016-T18	HLJ	C. grandis
PX453263	0.127
PX453266	0.027	0.125
PX453267	0.120	0.027	0.125
PX453268	0.110	0.144	0.118	0.139
PX453270	0.113	0.147	0.121	0.142	0.003
PX453272	0.123	0.136	0.125	0.132	0.138	0.141
PX453258	0.213	0.189	0.210	0.185	0.205	0.208	0.204
PX453259	0.221	0.194	0.218	0.189	0.204	0.208	0.205	0.040
PX453261	0.218	0.194	0.213	0.189	0.207	0.210	0.209	0.040	0.040
PX453262	0.206	0.180	0.201	0.177	0.197	0.201	0.193	0.010	0.038	0.032
PX453264	0.218	0.191	0.212	0.185	0.206	0.210	0.203	0.046	0.040	0.028	0.041
PX453265	0.212	0.187	0.208	0.184	0.201	0.204	0.201	0.033	0.031	0.036	0.032	0.026
PX453269	0.220	0.197	0.219	0.193	0.205	0.209	0.213	0.039	0.037	0.042	0.041	0.038	0.025
PX453271	0.209	0.188	0.207	0.183	0.196	0.201	0.203	0.051	0.053	0.054	0.050	0.060	0.055	0.058
NJ-T-37	0.127	0.002	0.125	0.026	0.146	0.149	0.136	0.190	0.195	0.195	0.181	0.191	0.188	0.198	0.189
2016-T18	0.109	0.127	0.115	0.124	0.120	0.123	0.043	0.195	0.200	0.200	0.185	0.198	0.192	0.205	0.197	0.129
HLJ	0.024	0.125	0.017	0.127	0.115	0.118	0.126	0.212	0.218	0.216	0.202	0.211	0.208	0.220	0.208	0.127	0.112
C. grandis	0.213	0.188	0.207	0.183	0.202	0.205	0.201	0.040	0.033	0.039	0.039	0.021	0.015	0.025	0.055	0.190	0.195	0.206
C. reniformis	0.213	0.186	0.207	0.180	0.200	0.203	0.201	0.039	0.032	0.037	0.038	0.022	0.016	0.026	0.053	0.187	0.193	0.206	0.004

蜱种 Tick species	检测样品数 No. detected samples	原虫检出率/%（阳性样品数/检测样品数） Protozoan positive rate/% (No. positive samples/No. detected samples)
蜱种 Tick species	检测样品数 No. detected samples	巴贝虫 Babesia	Colpodella	肾形虫 Colpoda	合计 Total
长角血蜱 H. longicornis
成蜱 Adult	55	1.82（1/55）	7.27（4/55）	7.27（4/55）	16.36（9/55）
若蜱 Nymph	16	0/16	3/16	4/16	7/16
幼蜱 Larva	12	0/12	0/12	0/12	0/12
小计 Subtotal	83	1.20（1/83）	8.43（7/83）	9.64（8/83）	19.28（16/83）
褐黄血蜱 H. flava
成蜱 Adult	2	0/2	0/2	1/2	1/2
若蜱 Nymph	9	0/9	0/9	0/9	0/9
幼蜱 Larva	32	0（0/32）	0（0/32）	0（0/32）	0（0/32）
小计 Subtotal	43	0（0/43）	0（0/43）	2.33（1/43）	2.33（1/43）

上海崇明血蜱原虫感染情况及其系统进化分析

Prevalence and phylogenetic analysis of protozoan in Haemaphysalis ticks from Chongming, Shanghai

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 5

参考文献 25

相关文章 15

编辑推荐

Metrics

本文评价

[1]	管毓威, 向昱龙, 周敬祝, 罗小龙, 孔雪雪, 张燕, 胡勇, 梁文琴. 贵州省3个自治州寄生蜱细菌群落多样性研究[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(3): 370-376.
[2]	朱昊天, 周勇志, 曹杰, 王亚楠, 张厚双, 徐前明, 周金林. 长角血蜱天冬氨酸蛋白水解酶8基因的鉴定及其抵抗田鼠巴贝虫感染作用的研究[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(4): 433-438.
[3]	任冀超, 甘露, 郑会珍, 冯秀娟, 崔泽云, 李佳欣, 金依璇, 张伟, 郭庆勇, 巴音查汗·盖力克, 李永畅. 驽巴贝虫metacaspase基因的克隆、表达、反应原性鉴定和生物信息分析[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(3): 325-331.
[4]	赵阳阳, 焦亮. 珠海市首例输入性人田鼠巴贝虫感染病例报道[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(3): 421-423.
[5]	徐慧, 费妍, 龚志红, 谢曙英, 徐芸, 刘俊朴, 谢婧姿, 周峰, 谢慧群. 以多脏器梗死为特征的人感染巴贝虫1例[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(2): 275-278.
[6]	纪鹏慧, 蒋甜甜, 贺志权, 王丹, 岳思宁, 李素华, 杨成运, 王昊, 张红卫, 周瑞敏. 河南省信阳地区家畜寄生蜱感染巴贝虫的分子流行病学调查[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(5): 567-572.
[7]	徐以勒, 李江峰, 张家祺, 余向华, 阮卫. 晚期癌症患者合并巴贝虫感染1例[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(3): 393-396.
[8]	孙家辉, 宋鹏, 陈木新, 周魇, 林琳, 陈家旭, 蔡玉春. 田鼠巴贝虫肽基脯氨酸异构酶基因的重组表达及功能分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(1): 29-35.
[9]	宋鹏, 蔡玉春, 卢艳, 艾琳, 陈木新, 陈韶红, 陈家旭. 田鼠巴贝虫丽水分离株小鼠感染模型的建立及其病理变化[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(4): 493-499.
[10]	周淑姮, 曾志伟, 刘维俊, 王加熊, 徐国英, 肖方震. 闽东地区野生动物寄生蜱感染梨形虫状况的调查及基因型分析[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(1): 76-83.
[11]	殷梦, 张皓冰, 陶奕, 姜斌, 刘华. 马拉龙和阿托伐醌 + 阿奇霉素在不同免疫状态小鼠体内的抗田鼠巴贝虫药效评价[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(5): 659-665.
[12]	王帆, 别双双, 张云, 宋静, 段兴德, 熊孟韬, 王剑, 江佳富, 高子厚, 董毅, 杜春红. 云南横断山中部山区小型兽类感染巴贝虫的分子流行病学调查[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(2): 278-282.
[13]	张艳, 徐爱芳, 张家祺, 姚立农, 辜恺龙, 薛立芝, 潘克女. 1例误诊为疟疾的田鼠巴贝虫病患者的鉴别诊断[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(4): 445-448.
[14]	王子玥, 杨益超, 陈智平, 石云良. 广西某猴场诺氏疟原虫和田鼠巴贝虫感染情况调查[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(4): 494-496.
[15]	李素华, 赵玉玲, 高丽君, 张雅兰, 周瑞敏, 钱丹, 杨成运, 刘颖, 鲁德领, 张红卫, 许汴利. 河南省信阳市发热伴血小板减少患者中巴贝虫感染的分子流行特征分析[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(1): 66-69.