基于EQ-5D-5L量表的甘肃省棘球蚴病患者手术前后生命质量研究

doi:10.12140/j.issn.1000-7423.2024.02.008

中国寄生虫学与寄生虫病杂志 ›› 2024, Vol. 42 ›› Issue (2): 182-190.doi: 10.12140/j.issn.1000-7423.2024.02.008

基于EQ-5D-5L量表的甘肃省棘球蚴病患者手术前后生命质量研究

刘泽航¹(), 张小娟², 杨国兵², 雷家希¹, 刘白雪¹, 王莹¹, 王芝依¹, 王东², 冯宇², 王立英¹^,^*()

1 中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心）；传染病溯源预警与智能决策全国重点实验室；国家卫生健康委员会寄生虫病原与媒介生物学重点实验室；世界卫生组织热带病合作中心；科技部国家级热带病国际研究中心，上海 200025
2 甘肃省疾病预防控制中心，兰州 730000

收稿日期:2024-01-02 修回日期:2024-01-24 出版日期:2024-04-30 发布日期:2024-04-22
通讯作者: * 王立英（1979—），女，博士，研究员，从事流行病与卫生统计学研究。E-mail：wangliyingcdc@163.com
作者简介:刘泽航（1998—），男，硕士研究生，主要从事传染病流行病学研究。E-mail：liuzehang1998@163.com
基金资助:
国家自然科学基金(81703281);甘肃省卫生行业科研计划(GSWSKY2017-19);国家卫生健康委包虫病防治研究重点实验室开放课题(2021WZK1006);中国疾病预防控制中心寄生虫病预防控制所科技创新支撑计划(TF2024005)

Assessment of the quality of life of patients with echinococcosis in Gansu Province pre- and post-surgery based on the EQ-5D-5L questionnaire

LIU Zehang¹(), ZHANG Xiaojuan², YANG Guobing², LEI Jiaxi¹, LIU Baixue¹, WANG Ying¹, WANG Zhiyi¹, WANG Dong², FENG Yu², WANG Liying¹^,^*()

1 National Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention; Chinese Centre for Tropical Diseases Research; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory of Parasite and Vector Biology, Ministry of Health; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China
2 Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730000, China

Received:2024-01-02 Revised:2024-01-24 Online:2024-04-30 Published:2024-04-22
Contact: * E-mail: wangliyingcdc@163.com
Supported by:
National Natural Science Foundation of China(81703281);Gansu Province Health Industry Scientific Research Plan Project(GSWSKY2017-19);NHC Key Laboratory of Echinococcosis Prevention and Control, China(2021WZK1006);Chinese Center for Disease Control and Prevention, Institute of Parasitic Diseases Prevention and Control, Science and Technology Innovation Support Program(TF2024005)

摘要/Abstract

摘要：

目的分析甘肃省棘球蚴病患者手术前后生命质量的变化，评价手术治疗措施对患者生命质量的影响。方法调查甘肃省中央转移支付地方棘球蚴病防治项目县中纳入项目管理并进行手术的棘球蚴病患者，采用调查问卷和EQ-5D-5L量表收集患者基本情况、首诊情况、手术情况和手术前后的生命质量情况。用SPSS 19.0、Origin 2021软件对数据进行统计学分析。结果共收集病例856例，其中男性417例，女性439例。年龄最小为7岁，最大为85岁，平均为53岁。CE患者737例，AE患者14例，未分型患者105例。棘球蚴病患者首次手术术后时间最长的为17.5年，最短的为1个月；调查时间与首次手术时间的平均时间间隔为7.4年（89个月）。棘球蚴病患者手术前后的健康效用值分别为0.910 ± 0.142和0.967 ± 0.067，术后较术前提高了6.3%（Z = -12.081，P < 0.05）；患者手术前后的视觉模拟标尺（VAS）评分分别为（79.10 ± 16.00）和（86.25 ± 11.64）分，术后较术前提高了9.0%（Z = -15.292，P < 0.05）。棘球蚴病患者的健康效用值差值和VAS评分差值的取值范围分别为[-0.308，1.348]和[-55，90]。42.8%（366/856）的棘球蚴病患者手术后健康效用值增加，62.7%（537/856）的患者手术后VAS评分增加。五维度困难程度减轻的占19.1%（818/4 280）；困难程度不变的占76.5%（3 275/4 280），整体健康状况不变组患者的术前健康效用值和VAS评分均高于其他组（Z = -16.580、-8.606，P < 0.05）；困难程度加重的占4.4%（187/4 280），健康效用值下降组患者的首次手术年龄高于其他组（Z = 4.393，P < 0.05）；VAS评分下降组患者的首次手术年龄高于其他组（Z = 3.154，P < 0.05）。趋势性检验结果显示，患者的健康效用值（F = 12.957，P_trend < 0.05）和VAS评分（F = 10.808，P_trend < 0.05）均与术后呈线性正相关趋势。结论手术治疗措施可改善棘球蚴病患者的生命质量。

关键词: 棘球蚴病, EQ-5D-5L量表, 手术患者, 生命质量, 甘肃省

Abstract:

Objective To analyse the changes in quality of life of patients with echinococcosis in Gansu Province pre- and post-surgery, and evaluate the impact of surgical treatments on the patients’ quality of life. Methods The patients with echinococcosis underwent surgery and were managed under the National Project for Echinococcosis Control and Prevention in Gansu Province were surveyed using questionnaire and EQ-5D-5L questionnaire to collect basic information, first visit record, surgical performance, and the quality of life pre- and post-surgery. The data were analyzed by SPSS 19.0 and Origin 2021. Results A total of 856 cases collected, including 417 males and 439 females. The age ranges from 7 to 85 years, with an average of 53 years. There were 737 cases of CE patients, 14 cases of AE patients, and 105 cases of unclassified patients. The longest time from the first surgery to postoperative follow-up for patients with echinococcosis was 17.5 years, and the shortest was 1 month. The average time interval between the investigation and the first surgery was 7.4 years (89 months). The preoperative and postoperative health utility values for patients with echinococcosis were 0.910 ± 0.142 and 0.967 ± 0.067, respectively, showing a 6.3% improvement postsurgery (Z = -12.081, P < 0.05). The preoperative and postoperative visual analog scale (VAS) scores were 79.10 ± 16.00 and 86.25 ± 11.64, respectively, showing a 9.0% improvement postsurgery (Z = -15.292, P < 0.05). The health utility value difference in patients with echinococcosis ranged between -0.308 and 1.348, the VAS score difference ranged between -55 and 90. A total of 42.8% (366/856) patients had an increase in health utility value postsurgery, and 62.7% (537/856) of patients had an increase in VAS score postsurgery. The proportion of patients with reduction of difficulties in the five dimensions was 19.1% (818/4 280), unchanged was 76.5% (3 275/4 280), and those with stable overall health had higher health utility values (Z = -16.580, P < 0.05) and VAS scores (Z = -8.606, P < 0.05). The proportion of patients with increased difficulties was 4.4% (187/4 280), the average age of first operation in the group with decreased health utility value was higher than that in another group (Z = 4.393, P < 0.05). The average age of first operation in the group with decreased VAS score was higher than that in another group (Z = 3.154, P < 0.05). The patients’ health utility value (F = 12.957, P_trend < 0.05) and VAS score (F = 10.808, P_trend < 0.05) showed a trend of positive linear correlation with the extension of postsurgery time. Conclusion Surgical treatment could impact the quality of life for patients with echinococcosis.

Key words: Echinococcosis, EQ-5D-5L questionnaire, Surgical patients, Quality of life, Gansu Province

中图分类号:

R532.32

刘泽航, 张小娟, 杨国兵, 雷家希, 刘白雪, 王莹, 王芝依, 王东, 冯宇, 王立英. 基于EQ-5D-5L量表的甘肃省棘球蚴病患者手术前后生命质量研究[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(2): 182-190.

LIU Zehang, ZHANG Xiaojuan, YANG Guobing, LEI Jiaxi, LIU Baixue, WANG Ying, WANG Zhiyi, WANG Dong, FENG Yu, WANG Liying. Assessment of the quality of life of patients with echinococcosis in Gansu Province pre- and post-surgery based on the EQ-5D-5L questionnaire[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2024, 42(2): 182-190.

图/表 8

表1

图1

表2

图2

表3

表4

甘肃省856例棘球蚴病患者首次手术治疗前后EQ-5D-5L各维度各水平的分布情况

维度 Dimension	棘球蚴病患者人数（占比/%） No. patients with echinococcosis (Proportion/%)		CE患者人数（占比/%） No. patients with CE (Proportion/%)		AE患者人数（占比/%） No. patients with AE (Proportion/%)		未分型棘球蚴病患者人数（占比/%） No. patients with unclassified echinococcosis(Proportion/%)
维度 Dimension	手术前 Before surgery	手术后 After surgery	手术前 Before surgery	手术后 After surgery	手术前 Before surgery	手术后 After surgery	手术前 Before surgery	手术后 After surgery
行动能力 Mobility
没有困难 No problem	740(86.4)	792(92.5)	632(85.8)	676(91.7)	10(71.4)	13(92.9)	98(93.3)	103(98.1)
有一点困难 Slight problem	105(12.3)	64(7.5)	96(13.0)	61(8.3)	2(14.3)	1(7.1)	7(6.7)	2(1.9)
有中度困难 Moderate problem	7(0.8)	0	6(0.8)	0	1(7.1)	0	0	0
有严重困难 Severe problem	2(0.2)	0	1(0.1)	0	1(7.1)	0	0	0
极度困难 Extreme problem	2(0.2)	0	2(0.3)	0	0	0	0	0
自我照顾 Self-care
没有困难 No problem	752(87.9)	803(93.8)	645(87.5)	687(93.2)	10(71.4)	13(92.9)	97(92.4)	103(98.1)
有一点困难 Slight problem	90(10.5)	50(5.8)	81(11.0)	47(6.4)	2(14.3)	1(7.1)	7(6.7)	2(1.9)
有中度困难 Moderate problem	8(0.9)	3(0.4)	7(0.9)	3(0.4)	1(7.1)	0	0	0
有严重困难 Severe problem	3(0.4)	0	2(0.3)	0	1(7.1)	0	0	0
极度困难 Extreme problem	3(0.4)	0	2(0.3)	0	0	0	1(1.0)	0
日常活动 Usual activity
没有困难 No problem	677(79.1)	748(87.4)	574(77.9)	642(87.1)	10(71.4)	12(85.7)	93(88.6)	94(89.5)
有一点困难 Slight problem	146(17.1)	97(11.3)	137(18.6)	87(11.8)	2(14.3)	2(14.3)	7(6.7)	8(7.6)
有中度困难 Moderate problem	24(2.8)	8(0.9)	20(2.7)	5(0.7)	1(7.1)	0	3(2.9)	3(2.9)
有严重困难 Severe problem	6(0.7)	3(0.4)	4(0.5)	3(0.4)	1(7.1)	0	1(1.0)	0
极度困难 Extreme problem	3(0.4)	0	2(0.3)	0	0	0	1(1.0)	0
疼痛或不舒服 Pain or discomfort
没有疼痛或不舒服 No problem	468(54.7)	693(81.0)	393(53.3)	592(80.3)	9(64.3)	10(71.4)	66(62.9)	91(86.7)
有一点疼痛或不舒服 Slight problem	294(34.3)	157(18.3)	260(35.3)	140(19.0)	2(14.3)	4(28.6)	32(30.5)	13(12.4)
有中度疼痛或不舒服 Moderate problem	61(7.1)	6(0.7)	58(7.9)	5(0.7)	2(14.4)	0	1(1.0)	1(1.0)
有严重疼痛或不舒服 Severe problem	26(3.0)	0	20(2.7)	0	1(7.1)	0	5(4.8)	0
极度疼痛或不舒服 Extreme problem	7(0.8)	0	6(0.8)	0	0	0	1(1.0)	0
焦虑或沮丧 Anxiety/depression
没有焦虑或沮丧 No problem	587(68.6)	749(87.5)	498(67.6)	647(87.8)	8(57.1)	10(71.4)	81(77.1)	92(87.6)
有一点焦虑或沮丧 Slight problem	226(26.4)	100(11.7)	204(27.7)	85(11.5)	4(28.6)	4(28.6)	18(17.1)	11(10.5)
有中度焦虑或沮丧 Moderate problem	33(3.9)	6(0.7)	30(4.1)	5(0.7)	0	0	3(2.9)	1(1.0)
有严重焦虑或沮丧 Severe problem	9(1.1)	0	5(0.7)	0	2(14.3)	0	2(1.9)	0
极度焦虑或沮丧 Extreme problem	1(0.1)	1(0.1)	0	0	0	0	1(1.0)	1(1.0)

表4

表5

图3

参考文献 21

[1]	Wu WP, Wang H, Wang Q, et al. A nationwide sampling survey on echinococcosis in China during 2012—2016[J]. Chin J Parasitol Parasit Dis, 2018, 36(1): 1-14. (in Chinese)
	(伍卫平, 王虎, 王谦, 等. 2012—2016年中国棘球蚴病抽样调查分析[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(1): 1-14.)
[2]	Craig PS, McManus DP, Lightowlers MW, et al. Prevention and control of cystic echinococcosis[J]. Lancet Infect Dis, 2007, 7(6): 385-394. doi: 10.1016/S1473-3099(07)70134-2 pmid: 17521591
[3]	Wen H, Vuitton L, Tuxun T, et al. Echinococcosis: advances in the 21st century[J]. Clin Microbiol Rev, 2019, 32(2): e00075-18.
[4]	World Health Organization. Study protocol for the World Health Organization project to develop a Quality of Life assessment instrument (WHOQOL)[J]. Qual Life Res, 1993, 2(2): 153-159. pmid: 8518769
[5]	Herdman M, Gudex C, Lloyd A, et al. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)[J]. Qual Life Res, 2011, 20(10): 1727-1736. doi: 10.1007/s11136-011-9903-x pmid: 21479777
[6]	EuroQol Group. EuroQol: a new facility for the measurement of health-related quality of life[J]. Health Policy, 1990, 16(3): 199-208.
[7]	Luo N, Liu G, Li MH, et al. Estimating an EQ-5D-5L value set for China[J]. Value Health, 2017, 20(4): 662-669. doi: S1098-3015(16)34125-0 pmid: 28408009
[8]	Liu R, Zhang JF, Yan XL, et al. Comparative study of SF-36 and EQ-5D-5L in evaluating quality of life for patients with advanced schistosomiasis[J]. Chin J Parasitol Parasit Dis, 2021, 39(5): 639-646. (in Chinese)
	(刘蓉, 张剑锋, 严晓岚, 等. SF-36和EQ-5D-5L量表在晚期血吸虫病患者生命质量评价中的比较研究[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(5): 639-646.) doi: 10.12140/j.issn.1000-7423.2021.05.012
[9]	Mu QM, He W, Hou GM, et al. Comparative analysis of clinical curative effect and postoperative complications of laparoscopic and open surgery in patients with hepatic echinococcosis[J]. J Hunan Norm Univ Med Sci, 2018, 15(4): 14-17. (in Chinese)
	(母齐鸣, 贺伟, 侯桂敏, 等. 腹腔镜与开腹手术治疗肝包虫病患者的临床疗效及术后并发症对比分析[J]. 湖南师范大学学报(医学版), 2018, 15(4): 14-17.)
[10]	Khachatryan AS. Analysis of lethality in echinococcal disease[J]. Korean J Parasitol, 2017, 55(5): 549-553. doi: 10.3347/kjp.2017.55.5.549 pmid: 29103270
[11]	Guo M, Tuerganaili AJ, Ran B, et al. Analysis on the quality of life of hydatid patients in a hospital of Xinjiang[J]. Xinjiang Med J, 2019, 49(7): 671-675. (in Chinese)
	(郭敏, 吐尔干艾力•阿吉, 冉博, 等. 新疆某医院包虫病手术患者生存质量状况分析[J]. 新疆医学, 2019, 49(7): 671-675.)
[12]	Tian T. Investigation on disease burden of echinococcosis in high endemicity areas of Qinghai-Tibet Plateau[D]. Beijing: Chinese Center for Disease Control and Prevention, 2018: 24-29. (in Chinese)
	(田添. 青藏高原重点地区棘球蚴病的疾病负担研究[D]. 北京: 中国疾病预防控制中心, 2018: 24-29.)
[13]	Santivanez SJ, Arce M, Valcarcel M, et al. Lung and liver cystic echinococcosis factors associated with health-related quality of life after surgical treatment[J]. Am J Trop Med Hyg, 2017, 97(5): 149.
[14]	Chinese Doctor Association,Chinese College of Surgeons (CCS), Chinese Committee for Hadytidology (CCH). Expert consensus on diagnosis and treatment of hepatic cystic and alveolar echinococcosis (2019 edition)[J]. Chin J Dig Surg, 2019, 18(8): 711-721. (in Chinese)
	(中国医师协会外科医师分会包虫病外科专业委员会. 肝两型包虫病诊断与治疗专家共识(2019版)[J]. 中华消化外科杂志, 2019, 18(8): 711-721.)
[15]	Nikendei C, Greinacher A, Berkunova A, et al. Psychological burden and resilience factors in patients with alveolar echinococcosis: a cross-sectional study[J]. PLoS Negl Trop Dis, 2019, 13(1): e0007082.
[16]	Liao LJ, Peng SZ, Feng GJ, et al. Psychological analysis and nursing care of 80 patients with hepatic echinococcosis[J]. Nurs J Chin PLA, 2004, 21(9): 94-95. (in Chinese)
	(廖丽娟, 彭顺舟, 冯国君, 等. 肝包虫病患者80例心理分析及护理[J]. 解放军护理杂志, 2004, 21(9): 94-95.)
[17]	Velasco-Tirado V, Alonso-Sardón M, Lopez-Bernus A, et al. Medical treatment of cystic echinococcosis: systematic review and meta-analysis[J]. BMC Infect Dis, 2018, 18(1): 306. doi: 10.1186/s12879-018-3201-y pmid: 29976137
[18]	McManus DP, Gray DJ, Zhang WB, et al. Diagnosis, treatment, and management of echinococcosis[J]. BMJ, 2012, 344: e3866.
[19]	Schmidberger J, Steinbach J, Schlingeloff P, et al. Surgery versus conservative drug therapy in alveolar echinococcosis patients in Germany: a health-related quality of life comparison[J]. Food Waterborne Parasitol, 2019, 16: e00057.
[20]	Wang LY, Qin M, Liu ZH, et al. Prevalence and spatial distribution characteristics of human echinococcosis in China[J]. PLoS Negl Trop Dis, 2021, 15(12): e0009996.
[21]	Qin M, Wang LY, Wang Y, et al. Investigation on the management for patients with echinococcosis treated with albendazole: three PLADs, China, 2019[J]. China CDC Wkly, 2023, 5(20): 437-441.

维度 Dimension	有一点困难 Slight problems	有中度困难 Moderate problems	有严重困难 Severe problems	极度困难 Extreme problems
行动能力 Mobility	0.066	0.158	0.287	0.345
自我照顾 Self-care	0.048	0.016	0.210	0.253
日常活动 Usual activities	0.045	0.107	0.194	0.233
疼痛/不舒服 Pain/discomfort	0.058	0.138	0.252	0.302
焦虑/沮丧 Anxiety/depression	0.049	0.118	0.215	0.258

生命质量指标 Index of quality of life	[0，1）年（n = 40） [0, 1) year (n = 40)	[1，5）年（n = 215） [1, 5 ）years (n = 215)	[5，20] 年（n = 601） [5, 20] years (n = 601)	F₁	P	F₂	P_trend
健康效用值 Health utility value	0.932 ± 0.115	0.961 ± 0.072	0.971 ± 0.060	7.385	< 0.05	12.957	< 0.05
VAS评分/分 Visual analogue scalescore	81.55 ± 14.84	85.07 ± 12.17	86.99 ± 11.11	5.618	< 0.05	10.808	< 0.05

测量内容 Measurement contents	手术前 Before surgery	手术后 After surgery	Z值 Z value	P值 P value
棘球蚴病患者 Patients with echinococcosis
健康效用值 Health utility value	0.910 ± 0.142	0.967 ± 0.067	-12.081	< 0.05
VAS评分/分 Visual analogue scalescore	79.10 ± 16.00	86.25 ± 11.64	-15.292	< 0.05
CE患者 Patients with CE
健康效用值 Health utility value	0.909 ± 0.136	0.966 ± 0.067	-11.432	< 0.05
VAS评分/分 Visual analogue scalescore	79.08 ± 15.91	86.29 ± 11.12	-14.652	< 0.05
AE患者 Patients with AE
健康效用值 Health utility value	0.817 ± 0.320	0.955 ± 0.077	-1.906	> 0.05
VAS评分/分 Visual analogue scalescore	77.14 ± 18.78	79.29 ± 18.28	-0.400	> 0.05
未分型患者 Patients with unclassified echinococcosis
健康效用值 Health utility value	0.928 ± 0.143	0.974 ± 0.064	-3.642	< 0.05
VAS评分/分 Visual analogue scalescore	79.50 ± 16.43	86.91 ± 13.80	-5.092	< 0.05

五维度困难程度变化 Changes of five-dimensional difficulty degree	棘球蚴病患者人数（占比/%）No. patients with echinococcosis (Proportion/%)	CE患者人数（占比/%） No. patients with CE (Proportion/%)	AE患者人数（占比/%） No. patients with AE (Proportion/%)	未分型棘球蚴病患者人数（占比/%） No. patients with unclassified echinococcosis (Proportion/%)
行动能力 Mobility
减轻 Alleviated	91(10.6)	81(11.0)	4(28.6)	6(5.7)
不变 Unchanged	732(85.5)	624(84.7)	10(71.4)	98(93.3)
加重 Aggravated	33(3.9)	32(4.3)	0	1(1.0)
自我照顾 Self-care
减轻 Alleviated	83(9.7)	72(9.8)	4(28.6)	7(6.7)
不变 Unchanged	747(87.3)	640(86.8)	10(71.4)	97(92.4)
加重 Aggravated	26(3.0)	25(3.4)	0	1(1.0)
日常活动 Usual activity
减轻 Alleviated	134(15.7)	121(16.4)	4(28.6)	9(8.6)
不变 Unchanged	670(78.3)	572(77.6)	9(64.3)	89(84.8)
加重 Aggravated	52(6.1)	44(6.0)	1(7.1)	7(6.7)
疼痛/不舒服 Pain/discomfort
减轻 Alleviated	305(35.6)	266(36.1)	5(35.7)	34(32.4)
不变 Unchanged	499(58.3)	426(57.8)	7(50.0)	66(62.9)
加重 Aggravated	52(6.1)	45(6.1)	2(14.3)	5(4.8)
焦虑/沮丧 Anxiety/depression
减轻 Alleviated	205(23.9)	182(24.7)	5(35.7)	18(17.1)
不变 Unchanged	627(73.2)	536(72.7)	8(57.2)	83(79.0)
加重 Aggravated	24(2.8)	19(2.6)	1(7.1)	4(3.8)

基于EQ-5D-5L量表的甘肃省棘球蚴病患者手术前后生命质量研究

Assessment of the quality of life of patients with echinococcosis in Gansu Province pre- and post-surgery based on the EQ-5D-5L questionnaire

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 8

参考文献 21

相关文章 15

编辑推荐

Metrics

本文评价

[1]	蒉嫣, 薛垂召, 王旭, 刘白雪, 王莹, 王立英, 杨诗杰, 韩帅, 许学年. 2022年全国棘球蚴病防治工作进展[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(1): 8-16.
[2]	李奔福, 杨敬, 杨金玉, 罗瑞娟, 朱斌林, 陈泰林, 张丽娟, 李雪瑶, 严信留, 字金荣, 彭佳, 王正青, 李健雄, 蔡璇, 徐倩, 吴方伟, 杨亚明. 云南省大理州棘球蚴病流行病学调查和病例回顾性分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(5): 573-578.
[3]	倪碧娴, 徐祥珍, 张强, 唐凤, 张嘉尧, 茅范贞, 戴洋, 刘耀宝, 曹俊. 2015—2022年江苏省棘球蚴病网络报告病例流行病学特征分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(5): 636-639.
[4]	封晓晓, 白玛央金, 张颋, 陆豪杰, 魏黎明. 血清IgG唾液酸化修饰在肝棘球蚴病诊断中的应用研究[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(4): 434-439.
[5]	朱爱娅, 王旭, 王江友, 王颖, 李杨, 宋珊, 耿燕, 兰子尧, 戴佳芮. 贵州省儿童多房棘球蚴病1例[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(4): 520-523.
[6]	娆琬·托勒洪, 阿不都撒拉木·阿不力克木, 杨凌菲, 陈璐, 李钊, 贾芳, 宋涛. 超声表现诊断肝多房棘球蚴病的效果评价及因素分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(3): 312-318.
[7]	王威, 蔡辉霞. 2020年青海省棘球蚴病监测结果[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(3): 319-324.
[8]	蒉嫣, 薛垂召, 王旭, 刘白雪, 王莹, 王立英, 杨诗杰, 韩帅, 伍卫平, 肖宁. 2021年全国棘球蚴病防治进展[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(2): 142-148.
[9]	马冰村, 刘玉英, 张甜甜, 雷雯, 马霄, 刘寿. 青海省棘球蚴病影响因素的病例对照研究[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(2): 183-191.
[10]	马慧, 种世桂, 陈根, 张伶慧, 秦俊梅, 赵玉敏. 多房棘球蚴病相关细胞信号通路的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(2): 223-227.
[11]	路伟民, 杨小涛, 朱瑛, 张鸿, 李霁伟, 王艳春. 儿童肺细粒棘球蚴病1例[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(2): 253-256.
[12]	曹得萍, 毋德芳, 庞明泉, 彭小红, 李大宇, 樊海宁. 棘球蚴病患者肠道菌群差异性分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(1): 103-107.
[13]	段红菊, 李凌杰, 吴向林, 闫芳, 齐蓉婷, 马天波. 2016—2021年宁夏细粒棘球蚴病手术患者住院费用及其影响因素分析[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(1): 75-80.
[14]	吴向林, 闫芳, 段红菊, 齐蓉婷, 马天波, 高建炜. 2021年宁夏多房棘球蚴病流行区犬和野外宿主感染情况[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(6): 717-722.
[15]	刘玉英, 张甜甜, 马霄, 雷雯, 马冰村, 刘寿. 青海省成年人棘球蚴病防治知识知晓情况及影响因素分析[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(6): 723-729.