寄生虫14-3-3蛋白的研究进展

摘要/Abstract

摘要：

14-3-3蛋白在寄生虫的生长发育和环境适应中起重要作用。近年来研究表明,该蛋白可以和许多信号蛋白（包括磷酸酶、激酶和一些跨膜受体等）结合,从而广泛参与调节,如信号转导、新陈代谢、细胞生长、细胞增殖分化、细胞凋亡、细胞周期调控等多种重要细胞生命活动。在寄生虫领域对其进行系统性研究,有助于理解其参与寄生虫生长发育的生物学功能及调控机制。本文从寄生虫14-3-3蛋白的基因鉴定、结构特征、生物学功能和应用前景等方面进行了综述。

关键词: 寄生虫, 14-3-3蛋白, 蛋白结构, 功能

Abstract:

The 14-3-3 protein plays an important role in parasite development and environmental adaptation. Recent studies have shown that the 14-3-3 protein can bind to a plethora of interacting signaling proteins including phosphatases, kinases and some transmembrane receptors, thus participating in a wide range of important regulatory processes, such as signal transduction, metabolism, cell growth, cell proliferation and differentiation, apoptotic cell death, and cell cycle control. Systematic studies on the 14-3-3 protein can advance our understanding of the biological functions and regulatory mechanisms of parasite growth and development. This review summarizes the gene identification, structure, biological functions and application potentials of the 14-3-3 protein in parasites.

Key words: Parasite, 14-3-3 protein, Protein structure, Function

中图分类号:

罗波, 李想, 周必英. 寄生虫14-3-3蛋白的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(2): 178-183.

Bo LUO, Xiang LI, Bi-ying ZHOU. Research development on 14-3-3 protein in parasites[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2018, 36(2): 178-183.

图/表 2

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寄生虫	蛋白亚型	GenBank登录号	参考文献
恶性疟原虫Plasmodium falciparum	-	AAC17516	Al Khedery B. 1999^[11]
诺氏疟原虫P. knowlesi	-	AF065986	Al Khedery B. 1999^[11]
布氏锥虫指名亚种Trypanosoma brucei brucei	Tau	BAD38893	Inoue M, et al. 2005^[16]
	Tau	BAD38894	Inoue M, et al. 2005^[16]
克氏锥虫Trypanosoma cruzi	-	AAT77756	Peel BA, et al. 2004^a
	-	AI069722	Porcel BM, et al. 2000^[17]
刚地弓形虫Toxoplasma gondii	-	AB012775	Koyama T, et al. 2001^[12]
犬新孢子虫Neospora caninum	-	NCU31542	Lally NC, et al. 1996^[13]
溶组织内阿米巴Entamoeba histolytica	3	GAT95698	Izumyama S, et al. 2016^a
	2	GAT93384	Izumyama S, et al. 2016^a
	1	GAT94640	Izumyama S, et al. 2016^a
柔嫩艾美球虫Eimeria tenella	-	AAD02687	Myers RW, et al. 1998^a
	-	CDJ38777	Reid AJ, et al. 2013^a
阴道毛滴虫Trichomonas vaginalis	Alpha	AAV83996	Cheng SYH, et al. 2004^a
十二指肠贾第鞭毛虫Giardia duodenalis	Epsilon	AAZ91664	Lalle M, et al. 2005^[18]

寄生虫	蛋白亚型	GenBank登录号	参考文献
曼氏血吸虫Schistosoma mansoni	Epsilon	AF195529	McGonigle S, et al. 2001^[19]
	Epsilon2	AF375996	McGonigle S, et al. 2002^[19]
	1	SMU24281	Schechtman D, et al. 1995^[20]
日本血吸虫S. japonicum	Epsilon	AF056930	Zhang Y, et al. 2000^[21]
日本血吸虫S. japonicum	1	AF000369	Zhang Y, et al. 1999^[22]
华支睾吸虫Clonorchis sinensis	Epsilon	AEO89649	Wang X, et al. 2012^[23]
麝猫后睾吸虫Opisthorchis viverrini	Epsilon	OON22233	Mitreva M, 2015^a
	Zeta	EL620504	Kafle A, etal. 2016^a
细粒棘球绦虫Echinococcus granulosus	1	AF207904	Siles-Lucas M, et al. 2001^[24]
	2	AF529418	Nunes CP, et al. 2002^a
	3	BF643012	Fernandez C, et al. 2002^[25]
多房棘球绦虫E. multilocularis	-	U63643	Siles-Lucas M, et al. 2001^[26]
	1	EMU63643	Schechtman D, et al. 2001^[27]
	2	AF529419	Nunes CP, et al. 2004^[28]
猪带绦虫Taenia solium	Zeta	AHB59733	You Y, et al. 2013^a
南方根结线虫Meloidogyne incognita	-	AF402309	Jaubert S, et al. 2002^[29]
犬钩口线虫Ancylostoma caninum	-	AW181798	McCarter J, et al. 1999^a
粪类圆线虫Strongyloides stercoralis	-	BG227867	McCarter J, et al. 1999^a
捻转血矛线虫Haemonchus contortus	-	BF423290	Blaxter ML, et al. 2000^a