中国寄生虫学与寄生虫病杂志

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抗菌肽抗寄生虫作用研究进展

刘泽华,赵俊龙*   

  1. 华中农业大学,农业微生物学国家重点实验室,武汉430070
  • 出版日期:2014-10-30 发布日期:2015-01-06

Progress on Parasiticidal Activity of Antimicrobial Peptides

LIU Ze-hua,ZHAO Jun-long*   

  1. State Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China
  • Online:2014-10-30 Published:2015-01-06

摘要:

抗菌肽是由生物体内特定基因编码、核糖体合成的一类小分子活性多肽,具有高效、抗菌谱广和免疫原性低等特点。研究发现,抗菌肽可抑制寄生虫生长发育甚至杀死寄生虫,有潜在的抗寄生虫应用价值。本文综述了近年来有关抗菌肽抗寄生虫作用的研究进展,并介绍了抗菌肽研究中存在的问题。

关键词: 抗菌肽, 原虫, 蠕虫, 作用机制

Abstract:

Antimicrobial peptides are a kind of gene encoded, ribosome synthesized, small molecular polypeptides that have high efficiency, wide antibacterial spectrum, and low immunogenicity. Many studies have indicated that antimicrobial peptides can inhibit the growth of parasites or even kill them. This paper reviews the research progress on parasiticidal activity of the antimicrobial peptides in recent years, and presents the problems in the research.

Key words: Antimicrobial peptide, Protozoa, Helminth, Mechanism