中国寄生虫学与寄生虫病杂志 ›› 2012, Vol. 30 ›› Issue (3): 17-188-190.

• 研究简报 • 上一篇    下一篇

山西省1例新发内脏利什曼病病例调查

蔡辉霞1,2,左素俊3,徐文兴4,伍卫平1 *,李俊1,徐克均5   

  1. 1 中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织疟疾、血吸虫病和丝虫病合作中心,上海 200025; 2 青海省地方病预防控制所,西宁 811602; 3 山西省疾病预防控制中心,太原 030012; 4 山西省妇幼保健院,太原 030012; 5 四川省甘孜藏族自治州疾病预防控制中心,康定 626000
  • 出版日期:2012-06-30 发布日期:2012-09-28

Survey on a New Case of Visceral Leishmaniasis in Shanxi Province

CAI Hui-xia1,2,ZUO Su-jun3,XU Wen-xing4,WU Wei-ping1 *,LI Jun1,XU Ke-jun5   

  1. 1 National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention;Laboratory of Parasite and Vector Biology,MOH;WHO Collaborating Center for Malaria,Schistosomiasis and Filariasis,Shanghai 200025,China; 2 Qinghai Provincial Institute for Endemic Disease and Control,Xining 811602,China; 3 Shanxi Center for Disease Control and Prevention,Taiyuan 030012,China; 4 Shanxi Hospital for Maternal and Children Health Care,Taiyuan 030012,China; 5 Ganzi Tibetan Autonomous Prefecture Center for Disease Control and Prevention,Kangding 626000,China
  • Online:2012-06-30 Published:2012-09-28

摘要: 2011年9月,山西省长治市疾病预防控制中心通过传染病网络直报系统报告1例幼儿内脏利什曼病新发病例。围绕该病例展开了相关的临床个案和现场流行病学调查。患儿,2岁,山西省长治市黄碾镇人。临床检查示患儿肝脾肿大,血常规检查示全血细胞呈持续性降低,骨髓病理涂片发现利杜体,rK39免疫诊断试条检测示强阳性,确诊为内脏利什曼病。患儿经葡萄糖酸锑钠治疗1个疗程(总剂量为150~200 mg/kg,分6 d注射,1次/d)后,症状明显好转。现场调查该病例所在地区无内脏利什曼病既往病例。居民家中犬和家养动物的数量较多。采用rK39免疫诊断试条对周围人群(17人)及部分家养动物(3只犬、1头羊和1只猫)血样进行检测,结果均为阴性。推测该地区存在内脏利什曼病潜在流行风险。

关键词: 内脏利什曼病, 山西省, 新发病例

Abstract: A new case of visceral leishmaniasis (kala-azar) was reported by Changzhi CDC of Shanxi Province in September 2011. The case was investigated clinically and epidemiologically. The patient was a two-year-old boy who lived in Huangnian Town of Changzhi County in Shanxi Province. Clinical examination showed hepatosplenomegaly, consistent decrease of blood cells and Leishman-Donovan body in the bone marrow smear. The rK39 immune diagnosis test showed strongly positive. The case was diagnosed as kala-azar. After one course treatment of sodium stibogluconate, the patient's condition improved markedly. There were no cases of kala-azar in this region historically. Blood samples of 17 individuals and 5 domestic animals including 3 dogs were all negative in the rK39 immunodiagnostic test. It is speculated that the potential risk of kala-azar transmission exists in this region.

Key words: Viseral leishmaniasis, Shanxi Province, New case