中国寄生虫学与寄生虫病杂志 ›› 2012, Vol. 30 ›› Issue (3): 13-196-200.

• 综述 • 上一篇    下一篇

白细胞介素-15抗寄生虫感染的研究进展

李佳缘1,2,李中原1,2,王燕1,2,朱兴全1,徐民俊1 *   

  1. 1 中国农业科学院兰州兽医研究所,家畜疫病病原生物学国家重点实验室,甘肃省动物寄生虫病重点实验室,兰州 730046; 2 华南农业大学兽医学院,广州 510642
  • 出版日期:2012-06-30 发布日期:2012-09-28

Research Advances of Interleukin-15 in Anti-parasitic Infection

LI Jia-yuan1,2, LI Zhong-yuan1,2, WANG Yan1,2, ZHU Xing-quan1, XU Min-Jun1 *   

  1. 1 State Key Laboratory of Veterinary Etiological Biology,Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute,CAAS,Lanzhou,730046,China; 2 College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642,China
  • Online:2012-06-30 Published:2012-09-28

摘要: 白细胞介素-15(IL-15)是一种可溶性细胞因子,作为多种免疫细胞的趋化因子参与并调节机体炎症反应及免疫反应。目前,IL-15的分子结构与受体得到广泛研究,其信号转导方式也取得了较大进展,然而其在寄生虫学上的研究起步较晚。本文对近年来IL?鄄15在抗蠕虫及原虫感染等方面的最新研究进展作一综述,并对其免疫增强作用机制和应用前景进行了展望,为进一步探索IL-15抗寄生虫免疫作用及其在寄生虫学的相关应用研究提供参考。

关键词: 白细胞介素-15, 抗寄生虫免疫, 蠕虫, 原虫

Abstract: Interleukin-15(IL-15) is a pro-inflammatory cytokine and also a chemotactic factor for a variety of immune cells, which participates in and regulates the inflammatory response and immune response to organisms. Up to now, the molecular structure and receptor of IL-15 have been widely researched, with important advances in its signal transduction way. However, its application in parasitology is still a relatively new topic. This article summarizes the latest research development of IL-15 in anti-parasitic infection, prospects its mechanism and application.

Key words: Interleukin-15 (IL-15), Anti-parasitic immunity, Helminth, Protozoan