中国寄生虫学与寄生虫病杂志 ›› 1985, Vol. 3 ›› Issue (4): 266-268.

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血吸虫病肝纤维化动物某些生化指标的检测及其意义

徐麦玲,马德颖,魏承慈,徐肇玥,徐佩佩,戈顺娣,陆明廉   

  1. 上海第一医学院传染病寄生虫病教研室; 上海第一医学院传染病寄生虫病教研室; 上海第一医学院传染病寄生虫病教研室; 上海第一医学院传染病寄生虫病教研室; 上海第一医学院药学系分析化学教研室; 上海第一医学院药学系分析化学教研室; 上海第一医学院药学系分析化学教研室
  • 收稿日期:2017-01-12 修回日期:2017-01-12 出版日期:1985-11-30 发布日期:2017-01-12

SIGNIFICANCE OF DETERMINATION OF SOME BIOCHEMICAL INDICES IN HEPATIC FIBROSIS OF ANIMAL SCHISTOSOMIASIS JAPONICA

  • Received:2017-01-12 Revised:2017-01-12 Online:1985-11-30 Published:2017-01-12

摘要: 观察了血吸虫病家兔感染前后、形成肝纤维化前后和吡喹酮灌胃给药前后的血清单胺氧化酶、粘蛋白、血浆游离脯氨酸和羟脯氨酸的动态变化。感染后血清单胺氧化酶和粘蛋白明显升高,血浆游离羟脯氨酸和脯氨酸显著降低。治疗后血清粘蛋白迅速显著降低,并回复到正常水平;血清单胺氧化酶也显著降低,但未恢复正常。这些生化指标在肝纤维化的早期诊断和疗效考核方面有一定参考价值。

关键词: 血吸虫病肝纤维化, 脯氨酸含量, 血清单胺氧化酶, 生化指标, 血浆游离, 血清粘蛋白, 胶原合成, 传染病, 寄生虫病, 游离脯氨酸

Abstract: In order to study the pathogenesis of hepatic fibrosis, serum monoamine oxidase, mucoprotein, plasma proline and hydroxyproline were determined on 7 rabbits infected with Schistosoma japonicum. After infection serum monoamine oxidase and mucoprotein increased markedly, while plasm hydroxyproline and proline decreased evidently. After pyquiton treatment serum mucoprotein rapidly decreased and returned to normal level; whereas serum monoamine oxidase also diminished significantly, but didn't return to normal. It is suggested these biochemical indices might be of value in the early diagnosis of hepatic fibrosis and the evaluation of the effectiveness of therapy in schistosomiasis.