CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2021, Vol. 39 ›› Issue (3): 386-392.doi: 10.12140/j.issn.1000-7423.2021.03.015
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HUANG Zi-yun1(), LV Fang-li1,2,3,*()
Received:
2020-09-21
Revised:
2020-11-19
Online:
2021-06-30
Published:
2021-07-05
Contact:
LV Fang-li
E-mail:609797774@qq.com;fanglilu@yahoo.com
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CLC Number:
HUANG Zi-yun, LV Fang-li. Solid organ transplantation and toxoplasmosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(3): 386-392.
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URL: https://www.jsczz.cn/EN/10.12140/j.issn.1000-7423.2021.03.015
病例信息 | 心脏移植 (42例) | 肝移植(20例) | 肾移植(32例) |
---|---|---|---|
年龄/岁 | 3~64 | 7~62 | 14~74 |
性别 | 男(19例),女(10例),未知(13例) | 男(5例),女(12例),未知(3例) | 男(20例),女(11例),未知(1例) |
D/R血清学 | D+/R-(27例),D-/R+(1例), 未知/R-(11例),未知/R+(1例), 未知(1例) | D+/R-(7例),D-/R+(5例), 未知/R-(2例),未知/R+(1例), D+/R+(4例),未知(1例) | D+/R-(20例),D-/R+(2例),未知/R-(1例),未知/R+(2例),D-/未知(1例),D+/未知(1例),未知(5例) |
预防药物 | 无(30例),PY + LKV(5例),TMP + SMX(2例),SF(1例),ATO(1例),PY + SDZ(1例) | 无(10例),TMP+SMX(4例),PY + SDZ + LKV(1例),未知(5例) | 无(10例),TMP + SMX(7例),SF(2例),未知(13例) |
免疫抑制药物 | P(25例),AZ(16例),CSA(15例),ATG(14例),MMF(6例),TAC(4例),MET(4例) | TAC(10例),MMF(8例),P(8例),CSA(5例),AZ(4例),MET(4例),ATG(2例) | CSA(18例),ATG(14例),P(12例),MMF(11例),AZ(8例),MET(7例),TAC(6例),OKT3(3例) |
移植后初始发病天数 | 5~30 d(15例),31~90 d(10例),91~365 d(8例),2~12年(2例),未知(7例) | 2~30 d(11例),31~90 d(3例),91~365 d(3例),未知(3例) | 16 h~30 d(18例),31~90 d(3例),91~365 d(6例),2~11年(5例) |
临床症状 | 发热(19例),脑炎(8例),肺炎(8例),呼吸窘迫(8例),播散性弓形虫病(8例),心肌炎(6例),神经系统症状(6例),脉络膜视网膜炎(3例) | 发热(10例),巨细胞病毒感染(8例),肺炎(5例),神经系统症状(3例),脑水肿(2例),败血症(2例),白细胞减少(2例) | 发热(10例),巨细胞病毒感染(8例),肺炎(5例),神经系统症状(3例),脑水肿(2例),败血症(2例),白细胞减少(2例) |
发病机制 | D+传染给R-(29例),隐性弓形虫感染活化(4例),未知(9例), | D+传染给R-(9例),隐性弓形虫感染的活化(10例),未知(1例) | D+传染给R-(20例),隐性弓形虫感染活化(6例),食用未煮熟肉类(2例),未知(4例), |
感染后治疗药物 | 无(13例),PY + SDZ(12例),PY + SDZ + LKV(3例),TMP + SMX(2例),CLR + PY(2例),PY(2例),PY + SDZ + SF + CLR(1例),PZA + SDZ + LKV(1例),TMP + PY + SDZ + SP(1例),ATO(1例),未知(4例 ) | 无(6例),PY + SDZ(3例),PY + SDZ + LKV(1例),TMP + SMX(4例),TMP + SMX + VA + MEM(1例),CLR + TMP + SMX(1例),SMX + AZM(1例),VA+PRL + TZP(1例),PY(1例),CAZ + CIP + TEC + FCA(1例) | 无(9例),PY + SDZ(7例),PY + SDZ + LKV(2例),TMP + SMX(2例),CLR + PY(3例),CLR + TMP + SMX(1例),SMX(1例),PY + SDZ + ATO(1例),VA + PY + CLR + LKV(1例),CLR + PY + TMP + SMX(1例),AZM(1例),未知(3例) |
预后 | 死亡(26例),存活(16例) | 死亡(10例),存活(10例) | 死亡(14例),存活(17例),未知(1例) |
参考文献 | 13-17, 30, 32, 37, 39, 40, 44-49 | 3, 19, 22, 23, 29, 38, 41, 50-58 | 7, 24-28, 59-71 |
[1] |
Hill D, Dubey JP. Toxoplasma gondii: transmission, diagnosis and prevention[J]. Clin Microbiol Infect, 2002,8(10):634-640.
doi: 10.1046/j.1469-0691.2002.00485.x |
[2] | Liu JF, Lv FL. Research progress of pulmonary toxoplasmosis[J]. J Trop Med, 2014,14(4):541-544. (in Chinese) |
( 刘晋锋, 吕芳丽. 肺弓形虫病研究进展[J]. 热带医学杂志, 2014,14(4):541-544.) | |
[3] |
Derouin F, Pelloux H. Prevention of toxoplasmosis in transplant patients[J]. Clin Microbiol Infect, 2008,14(12):1089-1101.
doi: 10.1111/j.1469-0691.2008.02091.x |
[4] |
Izadi M, Jonaidi Jafari N, Mahmoodzadeh Poornaki A, et al. Detection of Toxoplasma gondii from clinical specimens of patients receiving renal transplant using ELISA and PCR[J]. Nephrourol Mon, 2013,5(5):983-987.
doi: 10.5812/numonthly |
[5] | Galvan-Ramírez ML, Rincón Sanchez AR, Bernal Redondo RM. Chapter 10. Diagnostic of opportunistic parasites in liver transplantation[M] //Bruyn O, Peeters S. Parasitology research trends. New York: Nova Science Publishers, 2010: 219-254. |
[6] | La Hoz RM, Morris MI. Tissue and blood protozoa including toxoplasmosis, chagas disease, leishmaniasis, babesia, acanthamoeba, balamuthia, and naegleria in organ transplant recipients: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice[J]. Clin Transplant, 2019,33(9):e13546. |
[7] |
Campbell AL, Goldberg CL, Magid MS, et al. First case of toxoplasmosis following small bowel transplantation and systematic review of tissue-invasive toxoplasmosis following noncardiac solid organ transplantation[J]. Transplantation, 2006,81(3):408-417.
pmid: 16477228 |
[8] |
Hommann M, Schotte U, Voigt R, et al. Cerebral toxoplasmosis after combined liver-pancreas-kidney and liver-pancreas transplantation[J]. Transplant Proc, 2002,34(6):2294-2295.
doi: 10.1016/S0041-1345(02)03241-4 |
[9] |
Nasser QJ, Power RE, Eng MP, et al. Toxoplasmosis after a simultaneous pancreas and kidney transplantation[J]. Transplant Proc, 2004,36(9):2843-2844.
doi: 10.1016/j.transproceed.2004.10.009 |
[10] |
Seguro FS, Assis RA, Silveira PAA, et al. Toxoplasma gondii in the bone marrow after pancreas-kidney transplantation[J]. Br J Haematol, 2009,147(3):276.
doi: 10.1111/bjh.2009.147.issue-3 |
[11] |
Munir A, Zaman M, Eltorky M. Toxoplasma gondii pneumonia in a pancreas transplant patient[J]. South Med J, 2000,93(6):614-617.
pmid: 10881783 |
[12] |
Fernàndez-Sabé N, Cervera C, Fariñas MC, et al. Risk factors, clinical features, and outcomes of toxoplasmosis in solid-organ transplant recipients: a matched case-control study[J]. Clin Infect Dis, 2012,54(3):355-361.
doi: 10.1093/cid/cir806 |
[13] |
Muñoz P, Arencibia J, Rodríguez C, et al. Trimethoprim-sulfamethoxazole as toxoplasmosis prophylaxis for heart transplant recipients[J]. Clin Infect Dis, 2003,36(7):932-934.
doi: 10.1086/cid.2003.36.issue-7 |
[14] |
Montoya JG, Giraldo LF, Efron B, et al. Infectious complications among 620 consecutive heart transplant patients at stanford university medical center[J]. Clin Infect Dis, 2001,33(5):629-640.
pmid: 11486285 |
[15] |
McGregor CG, Fleck DG, Nagington J, et al. Disseminated toxoplasmosis in cardiac transplantation[J]. J Clin Pathol, 1984,37(1):74-77.
pmid: 6368601 |
[16] | Mastrobuoni S, Dell’aquila AM, Herreros J. Fatal Toxoplasma gondii dissemination in a heart transplant recipient: description of a case[J]. Case Rep Transplant, 2012,2012:524279. |
[17] |
Castagnini M, Bernazzali S, Ginanneschi C, et al. Fatal disseminated toxoplasmosis in a cardiac transplantation with seropositive match for Toxoplasma: should prophylaxis be extended?[J]. Transpl Immunol, 2007,18(2):193-197.
pmid: 18005867 |
[18] | Anthony CW. Disseminated toxoplasmosis in a liver transplant patient[J]. J Am Med Women’s Assoc 1972, 1972,27(11):601-603. |
[19] |
Barcán LA, Dallurzo ML, Clara LO, et al. Toxoplasma gondii pneumonia in liver transplantation: survival after a severe case of reactivation[J]. Transpl Infect Dis, 2002,4(2):93-96.
pmid: 12220246 |
[20] |
Fabiani S, Fortunato S, Bruschi F. Solid organ transplant and parasitic diseases: a review of the clinical cases in the last two decades[J]. Pathogens, 2018,7(3):65.
doi: 10.3390/pathogens7030065 |
[21] |
Autier B, Dion S, Robert-Gangneux F. The liver as an organ at risk for Toxoplasma transmission during transplantation: myth or reality?[J]. J Clin Pathol, 2018,71(9):763-766.
doi: 10.1136/jclinpath-2018-205066 |
[22] |
de la Luz Galván-Ramírez M, Sánchez-Orozco LV, Gutiérrez-Maldonado AF, et al. Does Toxoplasma gondii infection impact liver transplantation outcomes? A systematic review[J]. J Med Microbiol, 2018,67(4):499-506.
doi: 10.1099/jmm.0.000694 |
[23] | Sun Y, Yu LX. A case of Toxoplasma gondii encephalitis after orthotopic liver transplantation[J]. Chin J Organ Transpl, 2018,39(8):499-501. (in Chinese) |
( 孙雁, 于立新. 原位肝移植术后弓形虫脑炎一例[J]. 中华器官移植杂志, 2018,39(8):499-501.) | |
[24] | Gay J, Gendron N, Verney C, et al. Disseminated toxoplasmosis associated with hemophagocytic syndrome after kidney transplantation: a case report and review[J]. Transpl Infect Dis, 2019,21(5):e13154. |
[25] |
Rogers NM, Peh CA, Faull R, et al. Transmission of toxoplasmosis in two renal allograft recipients receiving an organ from the same donor[J]. Transpl Infect Dis, 2008,10(1):71-74.
pmid: 17605745 |
[26] |
Segall L, Moal MC, Doucet L, et al. Toxoplasmosis-associated hemophagocytic syndrome in renal transplantation[J]. Transpl Int, 2006,19(1):78-80.
pmid: 16359380 |
[27] |
Martina MN, Cervera C, Esforzado N, et al. Toxoplasma gondii primary infection in renal transplant recipients. Two case reports and literature review[J]. Transpl Int, 2011,24(1):e6-e12.
doi: 10.1111/tri.2010.24.issue-1 |
[28] | Hébraud B, Kamar N, Borde JS, et al. Unusual presentation of primary toxoplasmosis infection in a kidney-transplant patient complicated by an acute left-ventricular failure[J]. NDT Plus, 2008,1(6):429-432. |
[29] |
Botterel F, Ichai P, Feray C, et al. Disseminated toxoplasmosis, resulting from infection of allograft, after orthotopic liver transplantation: usefulness of quantitative PCR[J]. J Clin Microbiol, 2002,40(5):1648-1650.
doi: 10.1128/JCM.40.5.1648-1650.2002 |
[30] |
Patrat-Delon S, Gangneux JP, Lavoué S, et al. Correlation of parasite load determined by quantitative PCR to clinical outcome in a heart transplant patient with disseminated toxoplasmosis[J]. J Clin Microbiol, 2010,48(7):2541-2545.
doi: 10.1128/JCM.00252-10 |
[31] |
Colombo FA, Vidal JE, Penalva de Oliveira AC, et al. Diagnosis of cerebral toxoplasmosis in AIDS patients in Brazil: importance of molecular and immunological methods using peripheral blood samples[J]. J Clin Microbiol, 2005,43(10):5044-5047.
pmid: 16207959 |
[32] |
Fricker-Hidalgo H, Brion JP, Durand M, et al. Disseminated toxoplasmosis with pulmonary involvement after heart transplantation[J]. Transpl Infect Dis, 2005,7(1):38-40.
pmid: 15984948 |
[33] |
Mechain B, Garin YJ, Robert-Gangneux F, et al. Lack of utility of specific immunoglobulin G antibody avidity for serodiagnosis of reactivated toxoplasmosis in immunocompromised patients[J]. Clin Diagn Lab Immunol, 2000,7(4):703-705.
pmid: 10882677 |
[34] |
Held TK, Krüger D, Switala AR, et al. Diagnosis of toxoplasmosis in bone marrow transplant recipients: comparison of PCR-based results and immunohistochemistry[J]. Bone Marrow Transp, 2000,25(12):1257-1262.
doi: 10.1038/sj.bmt.1702457 |
[35] |
Dard C, Marty P, Brenier-Pinchart MP, et al. Management of toxoplasmosis in transplant recipients: an update[J]. Expert Rev Anti Infect Ther, 2018,16(6):447-460.
doi: 10.1080/14787210.2018.1483721 |
[36] |
Robert-Gangneux F, Meroni V, Dupont D, et al. Toxoplasmosis in transplant recipients, Europe, 2010—2014[J]. Emerg Infect Dis, 2018,24(8):1497-1504.
doi: 10.3201/eid2408.180045 |
[37] |
Petty LA, Qamar S, Ananthanarayanan V, et al. Cardiac toxoplasmosis after heart transplantation diagnosed by endomyocardial biopsy[J]. Transpl Infect Dis, 2015,17(5):719-722.
doi: 10.1111/tid.12415 pmid: 26094707 |
[38] | Ramanan P, Scherger S, Benamu E, et al. Toxoplasmosis in non-cardiac solid organ transplant recipients: a case series and review of literature[J]. Transpl Infect Dis, 2020,22(1):e13218. |
[39] |
Baden LR, Katz JT, Franck L, et al. Successful toxoplasmosis prophylaxis after orthotopic cardiac transplantation with trimethoprim-sulfamethoxazole[J]. Transplantation, 2003,75(3):339-343.
pmid: 12589155 |
[40] | Strabelli TM, Siciliano RF, Vidal Campos S, et al. Toxoplasma gondii myocarditis after adult heart transplantation: successful prophylaxis with pyrimethamine[J]. J Trop Med, 2012,2012:853562. |
[41] |
Webb GJ, Shah H, David MD, et al. Post-prophylaxis Toxoplasma chorioretinitis following donor-recipient mismatched liver transplantation[J]. Transpl Infect Dis, 2016,18(5):805-808.
doi: 10.1111/tid.12589 pmid: 27500398 |
[42] |
Conrad A, Le Maréchal M, Dupont D, et al. A matched case-control study of toxoplasmosis after allogeneic haematopoietic stem cell transplantation: still a devastating complication[J]. Clin Microbiol Infect, 2016,22(7):636-641.
doi: 10.1016/j.cmi.2016.04.025 |
[43] |
Kortagere S. Novel molecules to treat chronic central nervous system toxoplasmosis[J]. J Med Chem, 2017,60(24):9974-9975.
doi: 10.1021/acs.jmedchem.7b01663 |
[44] |
Wreghitt TG, Hakim M, Gray JJ, et al. Toxoplasmosis in heart and heart and lung transplant recipients[J]. J Clin Pathol, 1989,42(2):194-199.
pmid: 2493490 |
[45] |
Hermanns B, Brunn A, Schwarz ER, et al. Fulminant toxoplasmosis in a heart transplant recipient[J]. Pathol Res Pract, 2001,197(3):211-215.
pmid: 11314787 |
[46] |
Baliu C, Sanclemente G, Cardona M, et al. Toxoplasmic encephalitis associated with meningitis in a heart transplant recipient[J]. Transpl Infect Dis, 2014,16(4):631-633.
doi: 10.1111/tid.12242 pmid: 24903646 |
[47] |
Michaels MG, Wald ER, Fricker FJ, et al. Toxoplasmosis in pediatric recipients of heart transplants[J]. Clin Infect Dis, 1992,14(4):847-851.
pmid: 1576279 |
[48] | Dávila V, Roncancio-Villamil G, Correa LA, et al. Disseminated toxoplasmosis in a heart transplant patient despite co-trimoxazole prophylaxis: a case report[J]. Biomedica, 2017,37(3):303-307. |
[49] |
Wreghitt TG, Gray JJ, Pavel P, et al. Efficacy of pyrimethamine for the prevention of donor-acquired Toxoplasma gondii infection in heart and heart-lung transplant patients[J]. Transpl Int, 1992,5(4):197-200.
pmid: 1418309 |
[50] |
Wendum D, Carbonell N, Svrcek M, et al. Fatal disseminated toxoplasmosis in a Toxoplasma seropositive liver transplant recipient[J]. J Clin Pathol, 2002,55(8):637.
pmid: 12147667 |
[51] |
Chiquet C, Fleury J, Blanc-Jouvan M, et al. Toxoplasmose oculaire acquise (panuvéite) après transplantation hépatique [Acquired ocular toxoplasmosis (panuveitis) after liver transplantation[J]. J Fr Ophtalmol, 2000,23(4):375-379.
pmid: 10794988 |
[52] |
Galván Ramírez ML, Castillo-de-León Y, Espinoza-Oliva M, et al. Acute infection ofToxoplasma gondii and cytomegalovirus reactivation in a pediatric patient receiving liver transplant[J]. Transpl Infect Dis, 2006,8(4):233-236.
pmid: 17116139 |
[53] |
Assi MA, Rosenblatt JE, Marshall WF. Donor-transmitted toxoplasmosis in liver transplant recipients: a case report and literature review[J]. Transpl Infect Dis, 2007,9(2):132-136.
pmid: 17461999 |
[54] |
Vaessen N, Verweij JJ, Spijkerman IJB, et al. Fatal disseminated toxoplasmosis after liver transplantation: improved and early diagnosis by PCR[J]. Neth J Med, 2007,65(6):222-223.
pmid: 17587652 |
[55] |
Caner A, Dökaya M, Karasu Z, et al. Incidence and diagnosis of active Toxoplasma infection among liver transplant recipients in Western Turkey[J]. Liver Transpl, 2008,14(10):1526-1532.
doi: 10.1002/lt.21558 |
[56] | Miltgen G, Paillot J, Vanlemmens C, et al. Fatal acute respiratory distress by Toxoplasma gondii in a Toxoplasma seronegative liver transplant recipient[J]. New Microbiol, 2016,39(2):160-162. |
[57] |
Singh N, Gayowski T, Marino IR. Toxoplasma gondii pneumonitis in a liver transplant recipient: implications for diagnosis[J]. Liver Transpl, 1996,2(4):299-300.
doi: 10.1002/(ISSN)1527-6473a |
[58] |
Uçkay I, Wunderli W, Giostra E, et al. False serologic evidence for acute primary toxoplasmosis during liver transplantation for fulminant hepatitis B: a case report[J]. Transplant Proc, 2009,41(10):4425-4427.
doi: 10.1016/j.transproceed.2009.09.081 |
[59] |
Karras A, Thervet E, Legendre C, et al. Hemophagocytic syndrome in renal transplant recipients: report of 17 cases and review of literature[J]. Transplantation, 2004,77(2):238-243.
doi: 10.1097/01.TP.0000107285.86939.37 |
[60] |
Giordano LFC, Lasmar EP, Tavora ERF, et al. Toxoplasmosis transmitted via kidney allograft: case report and review[J]. Transplant Proc, 2002,34(2):498-499.
doi: 10.1016/S0041-1345(02)02607-6 |
[61] |
Manz T, Grotz W, Orszagh M, et al. A patient with neurological deficits and seizures after renal transplantation[J]. Nephrol Dial Transplant, 2001,16(3):631-633.
doi: 10.1093/ndt/16.3.631 |
[62] |
Renoult E, Georges E, Biava MF, et al. Toxoplasmosis in kidney transplant recipients: report of six cases and review[J]. Clin Infect Dis, 1997,24(4):625-634.
pmid: 9145736 |
[63] | Schmidt B, Wieneke H, Fahrenkamp A, et al. Encephalitic and myocardial toxoplasmosis masquerading as cytomegalovirus infection in a renal allograft recipient[J]. Nephrol Dial Transplant, 1995,10(2):284-286. |
[64] |
Mejia G, Leiderman E, Builes M, et al. Transmission of toxoplasmosis by renal transplant[J]. Am J Kidney Dis, 1983,2(6):615-617.
pmid: 6342373 |
[65] |
Wulf MW, van Crevel R, Portier R, et al. Toxoplasmosis after renal transplantation: implications of a missed diagnosis[J]. J Clin Microbiol, 2005,43(7):3544-3547.
pmid: 16000502 |
[66] |
Clissold R, Bingham C. Late presentation of toxoplasmosis in renal transplant recipients[J]. NDT Plus, 2010,3(5):480-482.
doi: 10.1093/ndtplus/sfq113 pmid: 25984060 |
[67] |
Vaughan LB, Wenzel RP. Disseminated toxoplasmosis presenting as septic shock five weeks after renal transplantation[J]. Transpl Infect Dis, 2013,15(1):E20-E24.
doi: 10.1111/tid.2013.15.issue-1 |
[68] |
Shamim S, Mukherjee A, Bal C, et al. Cerebral toxoplasmosis masquerading CNS lymphoma on FDG PET-CT in post renal transplant patient[J]. Indian J Nucl Med, 2017,32(2):148.
doi: 10.4103/0972-3919.202254 |
[69] |
Bagchi S, Sachdev SS, Nalwa A, et al. Multiple intracranial space-occupying lesions in a renal transplant recipient from an area endemic for tuberculosis (TB): TB vs. toxoplasmosis[J]. Transpl Infect Dis, 2014,16(5):838-842.
doi: 10.1111/tid.12262 pmid: 25040057 |
[70] |
Lanfranco L, Olle Delahaye P, Dorr G, et al. Late isolated ocular toxoplasmosis in a belatacept-treated kidney transplant patient[J]. Transpl Int, 2016,29(12):1352-1353.
doi: 10.1111/tri.12853 |
[71] | Da Cunha S, Ferreira E, Ramos I, et al. Cerebral toxoplasmosis after renal transplantation. Case report and review[J]. Acta Med Port, 1994,7(Suppl 1):S61-S66. |
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