CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2020, Vol. 38 ›› Issue (6): 764-770.doi: 10.12140/j.issn.1000-7423.2020.06.015

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Research advances on the innate immunity mechanisms against Toxoplasma gondii

DU Kai-ge(), ZHUO Xun-hui, LU Shao-hong*()   

  1. Institute of Parasitic Diseases, Zhejiang Academy of Medical Science, Hangzhou 310000, China
  • Received:2020-02-28 Online:2020-12-30 Published:2021-01-12
  • Contact: LU Shao-hong;
  • Supported by:
    National Natural Science Foundation of China(81871684);National Natural Science Foundation of China(81802037);Key Research and Development Project of Zhejiang Province(2019C03057)


The innate immunity is the first defense line against invasion of pathogenic microorganisms. Toxoplasma gondii infection induces effective innate immune responses in the host, which play an important role in restricting Toxoplasma gondii infection and promoting the adaptive immunity. In the innate immunity, the pattern recognition receptors, immune cells and cytokines hold their respective roles while on the other hand interacting with each other, constituting a complex but ordered network. Some regulatory mediators and transcription factors regulate signaling transduction and gene expression, and participate in the defense response, autophagy and other biological processes. In this paper, we review the research progress of host innate immunity against T. gondii, to provide scientific basis for control of the parasite.

Key words: Toxoplasma gondii infection, Innate immunity, Interferon-γ

CLC Number: